Related Experiment Video

Updated: Sep 12, 2025

Optimized Management of Endovascular Treatment for Acute Ischemic Stroke
09:21

Optimized Management of Endovascular Treatment for Acute Ischemic Stroke

Published on: January 18, 2018

12.1K

Antihypertensive Drugs after Thrombectomy in Acute Ischemic Stroke with Poor Collateral Are Associated with

Wen Yin1, Hongye Xu1, Jiaming Mao2

  • 1Neurovascular Center, Changhai Hospital, Naval Medical University, Shanghai, China.

Cerebrovascular Diseases (Basel, Switzerland)
|August 6, 2025
PubMed

Insights

Antihypertensive drugs may worsen outcomes for acute ischemic stroke patients with poor collateral status after endovascular thrombectomy. Caution is advised when using these medications in this patient group.

Area of Science:

  • Neurology
  • Cardiology
  • Radiology

Background:

  • The effect of antihypertensive drugs on functional outcomes after endovascular thrombectomy for acute ischemic stroke is debated.
  • Collateral status may influence this relationship.

Purpose of the Study:

  • To investigate the combined impact of collateral status and antihypertensive drug use on functional outcomes in acute ischemic stroke patients undergoing endovascular thrombectomy.

Main Methods:

  • Retrospective analysis of 372 acute ischemic stroke patients who underwent endovascular thrombectomy.
  • Patients were categorized by collateral status using hypoperfusion index ratio (HIR).
  • Functional outcome was assessed using the 90-day modified Rankin Scale (mRS).

Main Results:

  • Antihypertensive drugs were associated with significantly higher odds of unfavorable outcomes (90-day mRS > 2) in patients with poor collateral status (HIR > 0.4).
  • No significant association was found in patients with good collateral status (HIR ≤ 0.4).
  • A statistically significant interaction was observed between antihypertensive drug use and collateral status.

Conclusions:

  • The association between antihypertensive drugs and functional outcomes after endovascular thrombectomy is dependent on collateral status.
  • Antihypertensive medications should be used cautiously in acute ischemic stroke patients with poor collateral status post-thrombectomy.
Abstract

Keywords:
Acute ischemic strokeAntihypertensive drugsCollateral statusFunctional outcome

More Related Videos

A Fibrin-Enriched and tPA-Sensitive Photothrombotic Stroke Model09:42

A Fibrin-Enriched and tPA-Sensitive Photothrombotic Stroke Model

Published on: June 4, 2021

2.9K
A Thrombotic Stroke Model Based On Transient Cerebral Hypoxia-ischemia06:01

A Thrombotic Stroke Model Based On Transient Cerebral Hypoxia-ischemia

Published on: August 18, 2015

15.0K

Related Concept Videos

Venous Thrombosis III: Interprofessional Care01:29

Venous Thrombosis III: Interprofessional Care

Venous thrombosis requires effective prevention and treatment strategies to improve patient outcomes and reduce potential complications.Prevention StrategiesHealthcare providers must prioritize preventing venous thromboembolism (VTE) for all adult patients upon admission. Interventions depend on bleeding and thrombosis risk, medical history, current medications, diagnoses, planned procedures, and patient preferences. Patients on bed rest should change positions every two hours and, if not...
22
Anticoagulant Drugs: Vitamin K Antagonists and Direct Oral Anticoagulants01:18

Anticoagulant Drugs: Vitamin K Antagonists and Direct Oral Anticoagulants

Oral anticoagulants are vital tools in preventing and treating blood clotting disorders. This diverse class of medications can be categorized as vitamin K antagonists, exemplified by warfarin, and direct thrombin inhibitors (DTIs), such as dabigatran, as well as factor Xa inhibitors, including rivaroxaban.
Warfarin, a prominent vitamin K antagonist family member, exerts its effect by inhibiting the enzyme VKORC1 (vitamin K epoxide reductase complex 1). By hindering this enzyme, warfarin...
1.3K
Anticoagulant Drugs: Low-Molecular-Weight Heparins01:30

Anticoagulant Drugs: Low-Molecular-Weight Heparins

Hemostasis is a crucial process that prevents excessive blood loss from damaged blood vessels. It involves various mechanisms such as vasoconstriction, platelet adhesion and activation, and fibrin formation. The importance of each mechanism depends on the type of vessel injury. In contrast, thrombosis is the abnormal formation of a blood clot within the blood vessels, leading to potential complications if the clot obstructs blood flow. Thrombosis can be caused by increased coagulability of the...
909
Pulmonary Embolism II: Diagnostic Studies and Interprofessional Care01:29

Pulmonary Embolism II: Diagnostic Studies and Interprofessional Care

Diagnosing Pulmonary EmbolismDiagnosing pulmonary embolism (PE) involves clinical assessment and advanced imaging tests. The preferred diagnostic tool is the spiral (helical) CT scan or CT angiography (CTA), which uses intravenous contrast media to visualize the pulmonary vasculature and identify emboli.A ventilation-perfusion (V/Q) scan is an alternative for patients unable to receive contrast media. This scan includes both perfusion and ventilation scanning. Perfusion scanning involves...
44
Acute Coronary Syndrome IV: Interprofessional Care01:28

Acute Coronary Syndrome IV: Interprofessional Care

IntroductionThe management of Acute Coronary Syndrome (ACS) aims to minimize myocardial damage, preserve myocardial function, and prevent complications.Initial ManagementInpatient management involves continuous cardiac monitoring, preferably in an ICU, focusing on blood pressure, serum sodium, potassium, and creatinine levels, and urine output. Ongoing pharmacologic management is crucial for stabilizing the patient.Supplemental Oxygen: Administer supplemental oxygen if oxygen saturation is...
28
Peripheral Artery Disease III: Interprofessional Care01:27

Peripheral Artery Disease III: Interprofessional Care

Peripheral Artery Disease (PAD) is characterized by narrowed arteries that diminish blood flow to the extremities. Effective management of PAD requires an interprofessional approach involving various healthcare professionals. The critical aspects of interprofessional care for PAD patients focus on risk factor modification, drug therapy, exercise therapy, nutrition therapy, critical limb ischemia care, and interventional radiology and surgical procedures.The primary treatment goal for PAD...
29