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Author Spotlight: Development and Characterization of a Mouse Model for Abdominal Aortic Aneurysm
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Inflammation, abdominal aortic aneurysm enlargement and rupture. Lessons learned from the Covid19 pandemic

Antonio V Sterpetti1, Francesca Miceli2, Alessia Digirolamo2

  • 1Department of Surgery Sapienza University Rome Italy, Italy.

Current Problems in Cardiology
|August 6, 2025
PubMed

Insights

Patients with moderate to severe COVID-19 may face increased risks of aortic aneurysm enlargement and rupture. COVID-19 infection can trigger mechanisms that accelerate aneurysm progression, posing a significant danger to affected individuals.

Area of Science:

  • Cardiovascular Medicine
  • Infectious Diseases
  • Aortic Aneurysm Research

Background:

  • COVID-19 is linked to various cardiovascular complications, including heart failure, ischemia, and thrombosis.
  • While aneurysms have been noted in COVID-19 patients, their degeneration and rupture correlation remains under-explored.

Purpose of the Study:

  • To analyze risk factors for aortic aneurysm enlargement and rupture in patients with moderate to severe COVID-19.
  • To investigate potential COVID-19-related mechanisms contributing to aortic aneurysm progression.

Main Methods:

  • Review of existing literature and case reports correlating COVID-19 infection with aortic aneurysm degeneration.
  • Analysis of proposed pathophysiological mechanisms linking viral infection to aneurysm instability.

Main Results:

  • COVID-19 infection may promote aortic aneurysm progression through enzymatic digestion of vessel walls, hypoxemia-induced thrombosis, and immune dysregulation.
  • Patients with pre-existing arterial aneurysms are identified as a high-risk group for rapid aneurysm expansion and rupture during severe COVID-19.

Conclusions:

  • Moderate to severe COVID-19 infection presents a potential risk for accelerated aortic aneurysm growth and rupture.
  • Understanding these mechanisms is crucial for managing patients with known aneurysms during COVID-19 infection.

Keywords:
Aortic aneurysmCovid19 infectonInflammationRupture

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