The SCVP and AECVP 'Seaport criteria' for lymphocytic myocarditis: Retrospective application to an autopsy cohort
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View abstract on PubMed
Summary
This summary is machine-generated.The Seaport criteria offer a feasible way to standardize lymphocytic myocarditis diagnosis in autopsy hearts, improving consistency. Challenges persist in identifying myocyte injury, necessitating further validation.
Area Of Science
- Cardiovascular Pathology
- Forensic Medicine
- Histopathology
Background
- Diagnosing lymphocytic myocarditis in non-biopsy samples is difficult due to sampling issues and interpretation variability.
- The Seaport criteria were introduced in 2025 by the SCVP and AECVP to standardize diagnosis.
- Lack of standardized criteria hinders accurate assessment of myocardial inflammation.
Purpose Of The Study
- To evaluate the practical application of the Seaport criteria in forensic autopsy cases.
- To assess the reclassification of lymphocytic-predominant myocardial inflammation using the Seaport criteria.
- To identify challenges in applying the Seaport criteria to autopsy specimens.
Main Methods
- Retrospective analysis of 93 autopsy cases with lymphocytic-predominant myocardial inflammation.
- Re-evaluation using the Seaport criteria, assessing technical requirements and inflammation patterns.
- Classification into diffuse, multifocal, focal myocarditis, or lymphocytic infiltrates of unknown significance (LIUS).
Main Results
- 82% of cases met minimum technical sampling standards; pediatric cases showed non-compliance.
- Original histological reports exhibited significant variability in terminology and detail.
- Reclassification yielded 36 diffuse myocarditis, 27 multifocal, 2 focal, and 28 LIUS cases; myocyte injury interpretation was challenging.
Conclusions
- The Seaport criteria are feasible for classifying lymphocytic myocarditis in autopsy hearts, promoting diagnostic standardization.
- Consistent application of the Seaport criteria can improve diagnostic accuracy.
- Further prospective, multicenter studies are recommended to validate these findings, particularly regarding myocyte injury assessment.
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