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Tumorigenicity study of disodium glycyrrhizinate administered orally to mice
Abstract:
Disodium glycyrrhizinate (DG) was administered at concentrations of 0.15 (maximum tolerated dose), 0.08, 0.04 or 0% in the drinking-water to groups of 50, 70, 60 and 60 male B6C3F1 mice, respectively. Female groups, each consisting of 50 mice, were given DG in the drinking-water at concentrations of 0.3 (maximum tolerated dose), 0.15, 0.08 or 0%. Treatment was continued for 96 wk and the experiment was terminated at wk 110. There was no difference between treated and control groups in tumour incidence, in the latent period before tumours appeared or in the distribution of different types of tumour. Thus the long-term oral administration of DG to mice did not yield any evidence of chronic toxicity or tumorigenicity.
Insights
Long-term oral administration of Disodium glycyrrhizinate (DG) to mice showed no evidence of chronic toxicity or tumorigenicity. Studies found no significant differences in tumor incidence or type between DG-treated and control groups.
Area of Science:
- Toxicology
- Pharmacology
- Carcinogenesis
Background:
- Disodium glycyrrhizinate (DG) is derived from licorice root.
- Assessing the long-term safety and potential carcinogenicity of DG is crucial for its therapeutic applications.
Purpose of the Study:
- To evaluate the chronic toxicity and tumorigenicity of Disodium glycyrrhizinate (DG) in mice following long-term oral administration.
Main Methods:
- Male and female B6C3F1 mice were administered varying concentrations of DG in drinking water for 96 weeks.
- Dose levels included maximum tolerated doses and lower concentrations, with control groups receiving no DG.
- Tumor incidence, latency, and type distribution were monitored until study termination at 110 weeks.
Main Results:
- No significant differences were observed in tumor incidence between DG-treated groups and control groups.
- The latent period for tumor development and the distribution of tumor types were comparable across all experimental groups.
- No evidence of chronic toxicity or tumorigenicity was detected in mice exposed to DG.
Conclusions:
- Long-term oral administration of Disodium glycyrrhizinate (DG) did not induce chronic toxicity or tumorigenicity in mice.
- The findings suggest that DG is safe for long-term use at the tested concentrations.
- Further research may explore specific mechanisms of DG's safety profile.