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Synthesis of pisiferic acid analogues and their anti-adipogenic effect in 3T3-L1 adipocytes
Ayako Oshika1, Sayumi Ono1, Haruka Iwano1
1College of Pharmacy, Kinjo Gakuin University, 2-1723 Oomori, Moriyama, Nagoya, Aichi 463-8521, Japan.
Bioorganic & Medicinal Chemistry Letters
|August 6, 2025
Abstract:
12-O-alkyl, acyl, and phenylcarbamoyl, and 11-bromo-7-oxo analogues were prepared from pisiferic acid from Chamaecyparis pisifera, and evaluated anti-adipogenic activity. Among them, pisiferic acid and methyl 12-O-phenylcarbamoylpisiferic acid methyl ester showed relatively high anti-adipogenic effect in 3T3-L1 adipocytes and should be thought to be potential candidates for anti-obesity drug.

