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Measurements of Physiological Stress Responses in C. Elegans
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Physiological aspects of hormesis.

Elisa Mitiko Kawamoto1, Cristoforo Scavone1, Rosana Camarini1

  • 1Department of Pharmacology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil.

Progress in Brain Research
|August 6, 2025
PubMed
Summary
This summary is machine-generated.

Hormesis, a stress response, offers a new way to treat brain disorders by improving neural plasticity and cognitive function. This adaptive mechanism uses intermittent stress to boost protective genes and enhance brain resilience.

Keywords:
AgingCognitionHormesisMetabolismNeurodegenerationNeuroprotection

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Area of Science:

  • Neuroscience
  • Cellular Biology
  • Adaptation Biology

Background:

  • Hormesis is an adaptive cellular response to moderate, intermittent stress.
  • This biphasic dose-response phenomenon offers benefits like neural plasticity and improved cognition.
  • Common molecular pathways, including transcription factors like NF-κB, CREB, and Nrf2, are modulated by hormetic interventions.

Purpose of the Study:

  • To explore hormesis as a therapeutic framework for neurological and neuropsychiatric disorders.
  • To elucidate the molecular mechanisms underlying hormetic interventions.
  • To bridge traditional homeostasis concepts with modern neuroplasticity and resilience.

Main Methods:

  • Review of existing literature on hormesis and its applications in neuroscience.
  • Analysis of molecular pathways modulated by hormetic interventions (e.g., intermittent fasting, exercise).
  • Examination of the dose-response relationship between stress and biological outcomes.

Main Results:

  • Hormetic interventions enhance antioxidant and anti-inflammatory responses.
  • Modulation of transcription factors (NF-κB, CREB, Nrf2) leads to increased neuroprotective gene expression (BDNF, heat shock proteins).
  • An inverted U-shaped curve describes the relationship between stress and beneficial adaptations, with moderate stress being optimal.

Conclusions:

  • Hormesis presents a promising therapeutic strategy for neurological and neuropsychiatric disorders.
  • Understanding hormetic mechanisms allows for the development of personalized interventions.
  • This framework supports the development of treatments for neurodegenerative conditions and cognitive decline.