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Updated: Sep 12, 2025
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Manufacturing stresses do not differentially impact red blood cells from donors with diabetes
Celina Phan1,2, Elyn M Rowe3, Mahsa Yazdanbakhsh1,2
1Innovation and Portfolio Management, Canadian Blood Services, Edmonton, Alberta, Canada.
Background And Objectives:
With the rising prevalence of diabetes and expanded blood donor criteria in Canada, individuals with diabetes are increasingly contributing to the blood supply. However, little is known about how routine manufacturing affects red blood cells (RBCs) from this group. This study examined RBC differences in donors with type 1 (T1D) or type 2 diabetes (T2D) following processing to generate red cell concentrates (RCCs).
Materials And Methods:
Whole blood (WB) donations were collected from voluntary T1D (n = 12), T2D (n = 11) and non-diabetic age/sex-matched (n = 23) donors. Donations were processed via red cell filtration to generate RCCs. At donation, 2.7-mL of WB was collected into EDTA tubes, and 70 mL of processed RCCs was aliquoted into satellite bags. WB-EDTA tubes and RCC satellite bags were characterized on Day 2 post collection.
Results:
Donors with T1D and T2D had similar, but higher glycated haemoglobin (HbA1c) levels than matched controls (p < 0.001). Processing increased RBC count, haemoglobin and haematocrit in all groups (p < 0.0001). Donors with T2D had decreased mean corpuscular haemoglobin (MCH) and mean corpuscular haemoglobin concentration (MCHC) compared to controls, both pre and post processing (p < 0.05), with a similar trend in p50 (pre: p < 0.01; post: p < 0.05).
Conclusion:
Blood component manufacturing did not exacerbate stress on RBCs from donors with diabetes. Donors with T2D had altered MCH, MCHC and p50 compared to matched controls, which persisted after processing. These findings emphasize the importance of donor health on blood product quality.
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