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Optimizing Adrenaline Administration in Anaphylaxis: Clinical Practice Considerations and Safety Insights.
Motohiro Ebisawa1, Antonella Muraro2, Margitta Worm3
1Clinical Research Center for Allergy and Rheumatology, NHO Sagamihara National Hospital, Sagamihara, Kanagawa, Japan.
Clinical and Translational Allergy
|August 6, 2025
Summary
Adrenaline (epinephrine) is crucial for treating anaphylaxis, but proper use is vital. This review clarifies safe administration of adrenaline autoinjectors (AAIs) to improve patient outcomes in emergencies.
Area of Science:
- Emergency Medicine
- Pharmacology
Background:
- Anaphylaxis is a severe, life-threatening allergic reaction.
- Adrenaline (epinephrine) is the primary treatment, but its use is hindered by misconceptions.
Purpose of the Study:
- To review the clinical use of adrenaline autoinjectors (AAIs) for anaphylaxis.
- To discuss safety considerations and the pharmacokinetic/pharmacodynamic profiles of AAIs.
Main Methods:
- Comprehensive literature review of AAIs in anaphylaxis management.
- Analysis of safety data and pharmacokinetic/pharmacodynamic profiles.
Main Results:
- Intramuscular (IM) adrenaline is safe for anaphylaxis when administered correctly; training is essential.
- Intravenous (IV) administration requires specialized settings due to cardiovascular risks.
Conclusions:
- Adrenaline's benefits in anaphylaxis outweigh potential transient side effects.
- Adrenaline autoinjectors (AAIs) play a key role in improving patient outcomes during anaphylactic emergencies.
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