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Postural control evolution in Duchenne muscular dystrophy - longitudinal study
Cristhina Bonilha Huster Siegle1, Flaviana Kelly de Lima Maciel1, Pedro Claudio Gonsales de Castro2
1Human Movement Sciences Departament, Universidade Federal de São Paulo, Santos, Brazil.
Developmental Neurorehabilitation
|August 6, 2025
Summary
Postural control in individuals with Duchenne Muscular Dystrophy (DMD) declines significantly over 12 months, with worsening evident by 6 months. This decline is exacerbated by increased sensory demands during testing.
Area of Science:
- Neurology
- Biomechanics
- Rehabilitation Science
Background:
- Duchenne Muscular Dystrophy (DMD) is a progressive neuromuscular disorder affecting muscle strength and function.
- Postural control is crucial for mobility and independence in individuals with DMD.
- Understanding the progression of postural deficits is vital for timely interventions.
Purpose of the Study:
- To evaluate the longitudinal changes in postural control in individuals with DMD over one year.
- To determine how sensory system demands impact postural stability in DMD.
- To identify the rate of postural control deterioration in DMD patients.
Main Methods:
- A longitudinal study involving 16 individuals with DMD (Vignos stages 1-6).
- Postural control assessed using the Wii Balance Board and a modified Sensory Organization Test (MSOT).
- Analysis focused on Center of Pressure (COP) displacement velocity and area.
Main Results:
- A significant decline in postural control was observed in individuals with DMD over 12 months.
- Early signs of deterioration were apparent as early as 6 months into the study.
- Performance on the MSOT worsened progressively with increasing sensory challenges.
Conclusions:
- Postural control deteriorates progressively in individuals with DMD.
- The sensory systems are increasingly challenged as the disease progresses.
- Early monitoring of postural control is recommended for individuals with DMD.
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