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Depression mediates the association between lipid accumulation products and overactive bladder
Caijuan Huang1, Ying Xu1, Yibing Guan2
1Department of Hematology, The First Affiliated Hospital, and College of Clinical Medicine of Henan University of Science and Technology, Luoyang, China.
Scientific Reports
|August 6, 2025
Summary
Higher lipid accumulation product (LAP) levels are linked to an increased risk of overactive bladder (OAB). Depression partially mediates this association, highlighting a potential pathway for intervention.
Area of Science:
- Metabolic health and urology
- Public health and epidemiology
- Mental health and its physiological correlates
Background:
- The relationship between lipid accumulation product (LAP) and overactive bladder (OAB) remains unexplored.
- Understanding potential risk factors and mediating pathways for OAB is crucial for public health.
Purpose of the Study:
- To investigate the association between LAP and OAB.
- To examine the mediating role of depression in the LAP-OAB relationship.
Main Methods:
- Utilized data from seven cycles (2005-2018) of the National Health and Nutrition Examination Survey (NHANES).
- Employed multivariable logistic regression, restricted cubic splines (RCS), subgroup analysis, and Random Forest (RF) for analysis.
- Investigated mediation by depression using established analytical methods.
Main Results:
- A significant linear positive association was found between LAP and OAB (AOR: 1.158, P < 0.001).
- The highest quartile of LAP showed a significantly increased OAB prevalence (AOR: 1.320, P = 0.002) compared to the lowest.
- Female gender was identified as a significant interaction variable, and LAP was a key factor associated with OAB.
- Depression accounted for approximately 10% of the association between LAP and OAB.
Conclusions:
- There is a linear positive association between LAP and OAB, with a notable interaction effect by gender.
- Depression acts as a significant intermediate factor in the relationship between LAP and OAB.
- These findings suggest potential targets for OAB prevention and management strategies, considering metabolic factors and mental health.
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