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Updated: Sep 12, 2025

VDJ-Seq: Deep Sequencing Analysis of Rearranged Immunoglobulin Heavy Chain Gene to Reveal Clonal Evolution Patterns of B Cell Lymphoma
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Published on: December 28, 2015

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Excised DNA circles from V(D)J recombination promote relapsed leukaemia

Zeqian Gao1, James N F Scott1, Matthew P Edwards1,2

  • 1School of Molecular and Cellular Biology, Faculty of Biological Sciences, University of Leeds, Leeds, UK.

Nature
|August 6, 2025
PubMed
Summary

Excised signal circles (ESCs), by-products of V(D)J recombination, replicate and persist, unlike previously thought. Increased ESCs correlate with B cell acute lymphoblastic leukemia relapse, indicating a role in adverse cancer outcomes.

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