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Updated: Sep 12, 2025
08:58
Isolation and Identification of Waterborne Antibiotic-Resistant Bacteria and Molecular Characterization of their Antibiotic Resistance Genes
Published on: March 3, 2023
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Antimicrobial Resistance: Enzymes, Proteins, and Computational Resources
Saurav Kumar Mishra1, Kanchan Sharma1, John J Georrge1
1Department of Bioinformatics, University of North Bengal, District-Darjeeling, Siliguri, 734013, West Bengal, India.
Current Pharmaceutical Design
|August 7, 2025
Summary
Antimicrobial resistance (AMR) is a growing global health crisis driven by antibiotic misuse. Understanding resistance mechanisms and developing inhibitors are crucial to combat drug-resistant bacteria and improve patient outcomes.
Area of Science:
- Microbiology
- Molecular Biology
- Public Health
Background:
- Antimicrobial resistance (AMR) is a significant global health threat.
- It arises from antibiotic misuse and overuse, leading to drug-resistant bacteria.
- Factors like misdiagnosis and incomplete treatment exacerbate AMR.
Purpose of the Study:
- To elucidate the mechanisms of antimicrobial resistance.
- To highlight the clinical impact of AMR on patient outcomes.
- To incorporate recent World Health Organisation (WHO) data on the AMR crisis.
Main Methods:
- Review of scientific literature on AMR mechanisms.
- Analysis of clinical perspectives and patient outcomes.
- Inclusion of recent global AMR trends and WHO data.
- Exploration of potential inhibitors and computational resources for predicting resistance genes/proteins.
Main Results:
- Identified key enzymes and proteins involved in AMR.
- Emphasized the escalating impact of AMR on healthcare systems and patient prognoses.
- Highlighted recent global trends and the urgent need for action.
Conclusions:
- Understanding AMR mechanisms is vital for developing effective interventions.
- Inhibitors and computational tools show promise in combating antibiotic resistance.
- Addressing AMR requires a multifaceted approach, informed by global data and clinical insights.
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