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Geriatric Pharmacotherapy Case Series: Polypharmacy Leading to Acute Kidney Injury
Jelena Lewis1, Laura Tsu1, Fatema Haider1
1Chapman University School of Pharmacy, Irvine, California.
The Senior Care Pharmacist
|August 7, 2025
Summary
Older adults face higher risks of acute kidney injury (AKI) from medications. This case study highlights assessing and adjusting drug therapy to manage AKI in elderly patients, emphasizing common causes.
Area of Science:
- Nephrology
- Geriatric Medicine
- Clinical Pharmacology
Background:
- Older adults are disproportionately affected by acute kidney injury (AKI).
- Polypharmacy in elderly patients increases the risk of drug-induced AKI.
- AKI in older populations is associated with significant morbidity and mortality.
Purpose of the Study:
- To present a case study on managing acute kidney injury in an elderly patient.
- To review the assessment and therapeutic adjustment strategies for drug-induced AKI in older adults.
- To discuss common etiologies of AKI relevant to geriatric patients.
Main Methods:
- Case report analysis of an elderly patient with acute kidney injury.
- Review of medication regimen for potential nephrotoxic agents.
- Evaluation of comorbidities and their contribution to kidney injury.
- Assessment of therapeutic adjustments to manage AKI.
Main Results:
- Identified multiple medications as the likely cause of acute kidney injury.
- Demonstrated successful management through medication review and adjustment.
- Highlighted the vulnerability of the geriatric population to nephrotoxic effects of drugs.
Conclusions:
- Careful medication management is crucial for preventing and treating AKI in older adults.
- Individualized assessment and adjustment of pharmacotherapy are essential in geriatric patients.
- Understanding common AKI etiologies aids in optimizing care for elderly patients.
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