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Updated: Jun 17, 2026

Utilizing Time-Resolved Protein-Induced Fluorescence Enhancement to Identify Stable Local Conformations One α-Synuclein Monomer at a Time
Published on: May 30, 2021
Small Molecule Modulators of α-Synuclein Phase Separation
Debabrata Sarkar1, Sumangal Roychowdhury2, Rajeev Jain2,3
1Organic and Medicinal Chemistry Division, Indian Institute of Chemical Biology (CSIR-IICB), 4, Raja S. C. Mullick Road, Jadavpur, Kolkata 700032, India.
None:
Parkinson's disease (PD) is a progressive neurodegenerative condition that affects the brain's ability to control movement. The disease occurs when nerve cells of the brain become impaired. Alpha-synuclein protein (α-Syn) aggregation followed by fibrillation is a hallmark of PD. Recent studies showed that the liquid-liquid phase separation (LLPS) and droplet formation of α-Syn protein play a crucial role in the pathology of PD. We synthesized novel zwitterionic compounds (3), which inhibited α-Syn phase separation and subsequent formation of fibrillary aggregates in a concentration-dependent manner.
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