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An In Vitro Bladder Model of Catheter-Associated Urinary Tract Infection
Published on: June 24, 2025
The relationship between catheter-related bloodstream infection and multi-drug resistant bacteria: a five-year
Juan Li1, Yahua Zheng2, Jingjing Ma1
1Department of Nursing, Ningbo Medical Center LiHuili Hospital, Ningbo, China.
Background:
Catheter-related bloodstream infection (CRBSI) is a severe hospital-acquired infection primarily associated with using central venous catheters (CVCs). With the rise of antibiotic resistance and the emergence of multidrug-resistant organisms (MDROs), there is a growing concern about the relationship between MDROs and CRBSI.
Objective:
To explore the association between MDROs and CRBSI.
Methods:
A retrospective study was conducted on hospitalized patients with implanted CVCs over 54 months (January 2019 to June 2023).
Results:
We included 50,718 patients with indwelling central venous catheters; 122 were diagnosed with central venous CRBSI) The incidence of CRBSI was 0.24% (122/50,718 patients). The rate of MDRO infections among non-CRBSI patients was only 3.86%, while the rate among CRBSI patients was 62.30% (χ² = 1065.80, p < 0.001). After excluding factors related to age, gender, medical history, environmental factors (ward of residence, length of hospitalization), catheter factors (catheter placement site, duration of catheterization, number of insertions), and other factors (duration of fever, abnormal white blood cell counts, frequency of mechanical ventilation) associated with CRBSI infection, the odds ratio for MDROs was 4.63 (95% CI: 2.86-7.50; P < 0.001; Fully adjusted model).
Conclusion:
MDROs are independently associated with a higher incidence of CRBSI. These findings highlight the critical need for targeted infection control strategies against MDRO-associated CRBSI and formulate specific management strategies for these infections while promoting interdisciplinary collaboration to improve patient outcomes.
Insights
Multidrug-resistant organisms (MDROs) significantly increase the risk of catheter-related bloodstream infections (CRBSI) in patients with central venous catheters (CVCs). Targeted strategies are crucial to combat this association and improve patient outcomes.
Area of Science:
- Infectious Diseases
- Critical Care Medicine
- Hospital Epidemiology
Background:
- Catheter-related bloodstream infection (CRBSI) is a serious hospital-acquired infection linked to central venous catheters (CVCs).
- The increasing prevalence of multidrug-resistant organisms (MDROs) raises concerns about their role in CRBSI.
- Understanding the MDRO-CRBSI relationship is vital for effective infection control.
Purpose of the Study:
- To investigate the association between multidrug-resistant organisms (MDROs) and catheter-related bloodstream infections (CRBSI).
Main Methods:
- A retrospective study analyzed data from 50,718 patients with indwelling CVCs over 54 months (January 2019 to June 2023).
Main Results:
- The incidence of CRBSI was 0.24% (122 cases).
- MDRO infection rates were substantially higher in CRBSI patients (62.30%) compared to non-CRBSI patients (3.86%).
- After adjusting for confounding factors, MDROs showed a 4.63-fold increased odds of CRBSI (P < 0.001).
Conclusions:
- Multidrug-resistant organisms (MDROs) are independently linked to a higher incidence of CRBSI.
- Findings underscore the necessity for targeted infection control measures against MDRO-associated CRBSI.
- Developing specific management strategies and fostering interdisciplinary collaboration are essential for improving patient outcomes.
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