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Functional and Structural Insights Into Complex Formation Between OPTN Leucine Zipper Domain and RAB8A

Kei Okatsu1, Reika Kikuchi2,3, Noriyuki Matsuda3

  • 1Department of Chemistry, Graduate School of Science, Kyoto University, Kyoto, Japan.

Genes to Cells : Devoted to Molecular & Cellular Mechanisms
|August 7, 2025
PubMed
Summary

Optineurin (OPTN) regulates vesicular trafficking and selective autophagy by interacting with RAB8A. This interaction, elucidated by crystal structure, is crucial for recruiting ATG9A vesicles, highlighting OPTN's multifunctional role.

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