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Related Concept Videos

Microorganisms in Medicine and Therapeutics01:29

Microorganisms in Medicine and Therapeutics

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Microorganisms play a fundamental role in vaccine development, gene therapy, and therapeutic production. Their biological properties are harnessed to advance medicine and public health. Beyond immunization, microorganisms contribute to gut health, antibiotic synthesis, and genetic disease treatment.Live Attenuated and Inactivated VaccinesLive attenuated vaccines, such as the measles, mumps, and rubella (MMR) vaccine, utilize weakened forms of pathogens to closely resemble natural infections.
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The Roles of Bacteria and Fungi in Plant Nutrition02:11

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Plants have the impressive ability to create their own food through photosynthesis. However, plants often require assistance from organisms in the soil to acquire the nutrients they need to function correctly. Both bacteria and fungi have evolved symbiotic relationships with plants that help the species to thrive in a wide variety of environments.
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Factors Affecting the Risk of Infection01:26

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The hosts' susceptibility to infection depends on several factors. The integrity of the skin and mucous membranes helps protect the body against microbial attacks. When the skin is altered, the chance of infection, limb loss, and even death increases.
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Applications of Molecular Taxonomy01:20

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Molecular taxonomy has revolutionized the understanding and classification of bacteria, providing precise insights into their diversity, evolutionary relationships, and ecological roles. By utilizing molecular techniques such as DNA sequencing and fingerprinting, researchers have made significant strides in various fields related to bacterial studies.Resolving Taxonomic AmbiguitiesMolecular taxonomy has been instrumental in distinguishing closely related bacterial species initially thought to...
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Bacterial Flora of the Large Intestine01:29

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The gut microbiome is formed by a vast and diverse community of bacteria that colonizes our large intestine. These bacteria start residing in the gut from birth and continue diversifying throughout life, influenced by factors such as diet, lifestyle, and stress. The gut bacterial community also includes bacteria from food and those that enter the colon through the anus.
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What is Monogastric Digestion?01:50

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The human body contains a monogastric digestive system. In a monogastric digestive system, the stomach only contains one chamber in which it digests food. Several other animal species also have monogastric digestive systems, including pigs, horses, dogs, and birds. This chapter, however, focuses on the human digestive system.
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Related Experiment Video

Updated: Sep 12, 2025

Analysis of Interactions between Endobiotics and Human Gut Microbiota Using In Vitro Bath Fermentation Systems
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Microbiota-Host Interactions: Exploring Their Dynamics and Contributions to Human Diseases.

Siau Wui Chin1, Zheng Yao Low1, Wei Qi Tan1

  • 1School of Science, Monash University Malaysia, Jalan Lagoon Selatan, Bandar Sunway, Subang Jaya, Selangor, Malaysia.

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Bacterial dysbiosis, an imbalance in gut, skin, and oral microbiota, contributes to various diseases. Understanding these interactions is key to developing new therapies for conditions like IBS and acne.

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Area of Science:

  • Microbiology
  • Human Health
  • Disease Pathogenesis

Background:

  • Dysbiosis involves an imbalance in bacterial composition, leading to a loss of beneficial bacteria and an overgrowth of potentially pathogenic ones.
  • Factors like diet, lifestyle, age, and chemical exposures significantly contribute to bacterial dysbiosis.
  • Understanding bacterial dynamics is crucial for preventing and alleviating diseases linked to microbial imbalances.

Purpose of the Study:

  • To elucidate the dynamic roles of bacteria in maintaining human health.
  • To explore how bacteria-bacteria interactions influence the rise of antimicrobial resistance.
  • To detail the relationship between bacterial dysbiosis and specific diseases in the gut, skin, and oral cavity.

Main Methods:

  • This review synthesizes current knowledge on bacterial dysbiosis and its health implications.
  • It examines the intricate relationships within microbial communities across different human body sites.
  • The review discusses existing and emerging therapeutic strategies for restoring microbial balance.

Main Results:

  • Bacterial dysbiosis is implicated in diseases such as irritable bowel syndrome (IBS), inflammatory bowel disease (IBD), acne vulgaris (AV), atopic dermatitis (AD), periodontitis, and dental caries.
  • Bacteria-bacteria interactions may play a role in the increasing prevalence of antimicrobial resistance.
  • The review highlights the complex interplay of microbiota in maintaining host health.

Conclusions:

  • Restoring microbial balance through interventions like probiotics, prebiotics, synbiotics, microbiota transplantation, and phage therapy is essential for treating dysbiosis-related diseases.
  • Further research into bacterial interplays is vital for developing novel therapeutics.
  • Understanding dysbiosis is fundamental for advancing human health and combating antimicrobial resistance.