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Updated: Sep 12, 2025
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Assessing Mitochondrial Function in Sciatic Nerve by High-Resolution Respirometry
Published on: May 5, 2022
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The role of mitochondrial dysfunction in diabetes-associated cognitive dysfunction: A bibliometric analysis
Chen Wang1, Siyi He1, Lingling Wang1
1Department of Anesthesiology, Hainan General Hospital (Hainan Affiliated Hospital of Hainan Medical University), Haikou, China.
Journal of Alzheimer'S Disease : JAD
|August 7, 2025
Summary
Diabetes-associated cognitive dysfunction (DACD) research highlights mitochondrial dysfunction as key. Oxidative stress is a major focus, with mitophagy emerging as a promising therapeutic target for Alzheimer's disease.
Area of Science:
- Neuroscience
- Endocrinology
- Biomedical Research
Background:
- Diabetes mellitus is a common chronic disease.
- Diabetes-associated cognitive dysfunction (DACD) is a frequent complication.
- Mitochondrial dysfunction is implicated in DACD pathogenesis, but mechanisms are unclear.
Purpose of the Study:
- To analyze research trends in mitochondrial dysfunction and DACD over 15 years (2010-2024).
- To identify key research areas, influential publications, and emerging topics.
Main Methods:
- Bibliometric analysis of 309 papers from the Web of Science Core Collection.
- Utilized HistCite, R-bibliometrix, VOSviewer, and CiteSpace software.
- Systematic literature search and data aggregation.
Main Results:
- China was the most prolific country; University of Coimbra and Moreira PI/Li YS were leading institution/authors.
- USA, Texas Tech University, and Reddy PH were also key contributors.
- Co-citation analysis revealed oxidative stress as the largest cluster; keywords included Alzheimer's disease and oxidative stress.
- Mitophagy emerged as a significant recent research focus.
Conclusions:
- Oxidative stress is a central theme in DACD research.
- Mitophagy presents a potential therapeutic strategy for DACD.
- Mitophagy is likely to be a key area for future research in this field.
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