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Updated: Sep 12, 2025

Leaf Spray Mass Spectrometry: A Rapid Ambient Ionization Technique to Directly Assess Metabolites from Plant Tissues
Published on: June 21, 2018
Applications of paper spray ionization mass spectrometry in forensic science: A mini review
Sachil Kumar1, Tulsidas R Baggi2,3
1Amity Institute of Forensic Sciences, Amity University, Noida, Uttar Pradesh, India.
Abstract:
Paper spray ionization (PSI) has emerged as a key ambient ionization technique in microanalysis over the past decade, valued for its ease of use and minimal sample preparation. This study reviews PSI's applications in forensic science, covering areas such as biomolecules, drugs of abuse, inks, explosives, toxicology, and trace evidence. To achieve these objectives, electronic searches were performed across several databases-Scopus, Web of Science, Science Direct, and PubMed-covering publications from 2010 through December 2023, with a focus on English-language articles. This search strategy yielded 40 relevant studies, which were reviewed to assess PSI-MS's current capabilities and advancements. The review underscores Paper Spray Ionization Mass Spectrometry's (PSI-MS) versatility, particularly its compatibility with various sampling methods like dried blood spots, which enhances its utility for rapid point-of-care (POC) analysis. This capability facilitates the efficient analysis of biochemical and forensic samples while bypassing lengthy separation procedures, marking a significant advancement in forensic analysis techniques.
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