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Updated: Aug 19, 2026

Localization and Relative Quantification of Carbon Nanotubes in Cells with Multispectral Imaging Flow Cytometry
Published on: December 12, 2013
Carbon nanotube nanofluidics
Zhongwu Li1, Aleksandr Noy1,2
1Materials Science Division, Physical and Life Sciences Directorate, Lawrence Livermore National Laboratory, Livermore, CA 94550, USA. noy1@llnl.gov.
Abstract:
Fluid flow under extreme spatial confinement exhibits unusual physical behaviors. This nanofluidic transport regime is relevant to a variety of mass transport, separation, and energy production processes in biological and industrial systems. Carbon nanotubes (CNTs) offer a nearly ideal platform for exploring nanofluidic transport because of their extremely narrow, smooth, hydrophobic inner pores, which enable very fast molecular flow while providing strong selectivity. In this review, we aim to provide a comprehensive understanding of nanofluidics in CNTs, focusing on the basic physics of mass transport in CNTs, various experimental platforms developed to investigate these phenomena, and key results on the permeation of water, protons, and ions. We focus on the critical factors that influence transport efficiency and selectivity, such as slip flow and charge regulation in CNTs, and the roles of entrance effects, dehydration processes and ion-charge interactions at the CNT entrances. We also explore the confinement effects, highlighting how the unique one-dimensional structure of CNTs imposes distinct constraints on fluid behavior and leads to novel single-file transport phenomena. Finally, we address current challenges and future directions of CNT nanofluidics.
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