Related Experiment Video
Updated: Sep 12, 2025
05:05
Technique of Conjunctival Biopsy and Direct Immunofluorescence for Diagnosing Mucous Membrane Pemphigoid
Published on: June 17, 2025
278
Nail Involvement in Pemphigus: A Clinical and Dermoscopic Prospective Study
Anissa Zaouak1,2, Amal Chamli1,2, Oumayma Magdoud1,2
1Dermatology Department, Habib Thameur Hospital, Tunis, Tunisia.
Skin Appendage Disorders
|August 7, 2025
Summary
Nail involvement in pemphigus (NIP) can be severe and challenging to diagnose. Dermoscopy reveals key findings like onycholysis and subungual hemorrhage, aiding in distinguishing NIP from other nail disorders.
Area of Science:
- Dermatology
- Nail Diseases
Background:
- Nail involvement in pemphigus (NIP) is often underestimated and can indicate disease severity.
- Diagnosing NIP is challenging due to its potential to mimic other nail conditions.
Purpose of the Study:
- To provide an overview of NIP.
- To highlight the role of dermoscopy in identifying NIP.
Main Methods:
- A monocentric prospective study conducted from January 2018 to December 2022.
- Clinical and dermoscopic evaluation of patients with NIP.
Main Results:
- Six out of 32 patients had NIP, predominantly pemphigus vulgaris (83%).
- Most NIP cases (83%) were severe, with frequent exacerbations.
- Onycholysis and subungual hemorrhage were the most common dermoscopic findings (83%).
Conclusions:
- Dermoscopic features including subungual hemorrhage, onycholysis, and paronychia are crucial for differentiating NIP from other nail conditions.
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