Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Autoimmune Disorders01:29

Autoimmune Disorders

676
Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
Concept and Mechanism of Autoimmune Diseases
The immune...
676
What is the Immune System?01:38

What is the Immune System?

116.2K
Overview
116.2K
Combination Therapies and Personalized Medicine02:50

Combination Therapies and Personalized Medicine

5.1K
Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
5.1K
Psychoneuroimmunology: Diabetes and Cancer01:19

Psychoneuroimmunology: Diabetes and Cancer

62
Chronic stress has been linked to both the onset and progression of serious health conditions, including Type 2 diabetes and cancer. Type 2 diabetes, a widespread chronic illness, is closely associated with obesity and insulin resistance, both of which often worsen under stress. Studies indicate that men experiencing high levels of chronic stress face a 45% higher risk of developing diabetes compared to those with minimal stress. Stress triggers physiological responses that elevate blood...
62
Cross-reactivity00:42

Cross-reactivity

31.5K
Overview
31.5K
Inflammatory Bowel Disease IV: Pharmacological Management01:29

Inflammatory Bowel Disease IV: Pharmacological Management

190
Upon diagnosis, managing Inflammatory Bowel Disease (IBD) involves addressing several crucial aspects. The primary goals include resting the bowel, correcting malnutrition, and providing symptomatic relief. Resting the bowel may consist of medications to reduce inflammation and promote healing. Correcting malnutrition is essential, often requiring dietary adjustments and nutritional supplements. Symptomatic relief aims to ease pain, diarrhea, and other discomforts in IBD.
Pharmacologic...
190

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Dysregulated soluble immune mediators and lupus-associated autoantibody specificities inform the development of immune indexes that characterise classified SLE transition and SLE disease activity.

Lupus science & medicine·2025
Same author

A Randomized, Placebo-Controlled Trial of Hydroxychloroquine in Incomplete Lupus.

Arthritis & rheumatology (Hoboken, N.J.)·2025
Same author

Geographic Socioeconomic Influences on Disease Activity in Rheumatoid Arthritis in an Academic and Safety Net Hospital System.

ACR open rheumatology·2024
Same author

Prevalence of Antiphospholipid Antibodies and Association With Incident Cardiovascular Events.

JAMA network open·2023
Same author

Anti-Neutrophil Extracellular Trap Antibodies in Antiphospholipid Antibody-Positive Patients: Results From the Antiphospholipid Syndrome Alliance for Clinical Trials and InternatiOnal Networking Clinical Database and Repository.

Arthritis & rheumatology (Hoboken, N.J.)·2023
Same author

Editorial: Understanding the concept of pre-clinical autoimmunity.

Frontiers in immunology·2022

Related Experiment Video

Updated: Sep 12, 2025

High-Efficiency Generation of Antigen-Specific Primary Mouse Cytotoxic T Cells for Functional Testing in an Autoimmune Diabetes Model
11:31

High-Efficiency Generation of Antigen-Specific Primary Mouse Cytotoxic T Cells for Functional Testing in an Autoimmune Diabetes Model

Published on: August 16, 2019

8.0K

REDEFINING AUTOIMMUNE DISEASES: THE OPPORTUNITY FOR PRECISION AND PREVENTION.

David R Karp1

  • 1Dallas, TX.

Transactions of the American Clinical and Climatological Association
|August 7, 2025
PubMed
Summary

Autoimmune diseases impact 8% of the U.S. population. Identifying individuals at risk during the silent preclinical phase offers opportunities for early interventions and disease prevention.

More Related Videos

Single-cell Analysis of Immunophenotype and Cytokine Production in Peripheral Whole Blood via Mass Cytometry
12:36

Single-cell Analysis of Immunophenotype and Cytokine Production in Peripheral Whole Blood via Mass Cytometry

Published on: June 26, 2018

9.6K
Regulatory T cells: Therapeutic Potential for Treating Transplant Rejection and Type I Diabetes
16:26

Regulatory T cells: Therapeutic Potential for Treating Transplant Rejection and Type I Diabetes

Published on: August 20, 2007

5.9K

Related Experiment Videos

Last Updated: Sep 12, 2025

High-Efficiency Generation of Antigen-Specific Primary Mouse Cytotoxic T Cells for Functional Testing in an Autoimmune Diabetes Model
11:31

High-Efficiency Generation of Antigen-Specific Primary Mouse Cytotoxic T Cells for Functional Testing in an Autoimmune Diabetes Model

Published on: August 16, 2019

8.0K
Single-cell Analysis of Immunophenotype and Cytokine Production in Peripheral Whole Blood via Mass Cytometry
12:36

Single-cell Analysis of Immunophenotype and Cytokine Production in Peripheral Whole Blood via Mass Cytometry

Published on: June 26, 2018

9.6K
Regulatory T cells: Therapeutic Potential for Treating Transplant Rejection and Type I Diabetes
16:26

Regulatory T cells: Therapeutic Potential for Treating Transplant Rejection and Type I Diabetes

Published on: August 20, 2007

5.9K

Area of Science:

  • Immunology
  • Epidemiology
  • Public Health

Background:

  • Autoimmune diseases affect at least 8% of the U.S. population, representing a significant public health concern.
  • The development of autoimmune diseases involves a lengthy, clinically silent preclinical phase preceding tissue damage and organ dysfunction.
  • Current disease definitions focus on clinical manifestations, hindering early detection and intervention strategies.

Purpose of the Study:

  • To highlight the critical preclinical phase of autoimmune diseases as an opportunity for early detection and intervention.
  • To advocate for a shift from clinical to molecular definitions for more precise disease characterization.
  • To emphasize the need for large-scale epidemiological studies on immune dysfunction for autoimmune disease prevention.

Main Methods:

  • Review of accumulated evidence over the past 20+ years on autoimmune disease pathophysiology.
  • Analysis of the preclinical phase of chronic diseases for risk identification and intervention development.
  • Discussion on the necessity of large-scale epidemiological studies focusing on immune dysfunction.

Main Results:

  • The preclinical phase of autoimmune diseases is a critical window for intervention.
  • A transition to molecular definitions is essential for precise disease staging.
  • Large-scale epidemiological studies are crucial for understanding immune dysfunction.

Conclusions:

  • Early identification of individuals at risk during the preclinical phase can lead to interventions that mitigate disease impact or prevent onset.
  • Defining disease stages based on molecular characteristics will provide clarity for patients and a roadmap for researchers, industry, and regulators.
  • Advancing autoimmune disease prevention requires a concerted effort in epidemiological research and a redefinition of disease based on molecular insights.