Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Targeted Cancer Therapies02:57

Targeted Cancer Therapies

7.8K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
7.8K
Adaptive Mechanisms in Cancer Cells02:53

Adaptive Mechanisms in Cancer Cells

5.9K
Cancer cells accumulate genetic changes at an abnormally rapid rate due to the defects in the DNA repair mechanisms. From an evolutionary perspective, such genetic instability is advantageous for cancer development. Mutant cell lines accumulate a series of beneficial mutations that contribute to their progression into cancer.
Some of the advantages that cancer cells have on normal cells include - enhanced ability to divide without terminally differentiating, induce new blood vessel formation,...
5.9K
Combination Therapies and Personalized Medicine02:50

Combination Therapies and Personalized Medicine

5.1K
Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
5.1K
Electron Transport Chain: Complex I and II01:46

Electron Transport Chain: Complex I and II

15.0K
The mitochondrial electron transport chain (ETC) is the main energy generation system in the eukaryotic cells. However, mitochondria also produce cytotoxic reactive oxygen species (ROS) due to the large electron flow during oxidative phosphorylation. While Complex I is one of the primary sources of superoxide radicals, ROS production by Complex II is uncommon and may only be observed in cancer cells with mutated complexes.
ROS generation is regulated and maintained at moderate levels necessary...
15.0K
Cancer Therapies02:49

Cancer Therapies

7.9K
Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
7.9K
Metastasis02:30

Metastasis

5.7K
Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...
5.7K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Time-of-day of first checkpoint inhibitor dose influences clinical outcomes and immune responses in hepatocellular carcinoma.

Journal for immunotherapy of cancer·2026
Same author

Wnt signaling and the tumor microenvironment: implications for cancer progression and therapeutics.

Oncogene·2026
Same author

The HIF-2 transcription factor mediates resistance to ferroptosis in pancreatic cancer.

Molecular cell·2026
Same author

Androgen Receptor Drives Polyamine Synthesis, Creating a Vulnerability for Prostate Cancer.

Cancer research·2025
Same author

DNAJ-PKAc induces metabolic rewiring and enhanced glutamine flux in fibrolamellar HCC.

Journal of hepatology·2025
Same author

Imaging the uptake and metabolism of glutamine in prostate tumor models using CEST MRI.

Npj imaging·2025

Related Experiment Video

Updated: Sep 12, 2025

Assessment of the Metabolic Profile of Primary Leukemia Cells
06:21

Assessment of the Metabolic Profile of Primary Leukemia Cells

Published on: November 21, 2018

10.6K

OPPORTUNITIES AND CHALLENGES FOR TARGETING CANCER METABOLISM.

Chi V Dang1

  • 1Baltimore, MD.

Transactions of the American Clinical and Climatological Association
|August 7, 2025
PubMed
Summary
This summary is machine-generated.

Cancer cells rely on glucose metabolism, a vulnerability targeted for therapy. Understanding tumor metabolism is crucial for effective cancer treatment and immunotherapy.

More Related Videos

Utilizing Functional Genomics Screening to Identify Potentially Novel Drug Targets in Cancer Cell Spheroid Cultures
07:48

Utilizing Functional Genomics Screening to Identify Potentially Novel Drug Targets in Cancer Cell Spheroid Cultures

Published on: December 26, 2016

11.5K
Extraction of Aqueous Metabolites from Cultured Adherent Cells for Metabolomic Analysis by Capillary Electrophoresis-Mass Spectrometry
11:39

Extraction of Aqueous Metabolites from Cultured Adherent Cells for Metabolomic Analysis by Capillary Electrophoresis-Mass Spectrometry

Published on: June 9, 2019

9.2K

Related Experiment Videos

Last Updated: Sep 12, 2025

Assessment of the Metabolic Profile of Primary Leukemia Cells
06:21

Assessment of the Metabolic Profile of Primary Leukemia Cells

Published on: November 21, 2018

10.6K
Utilizing Functional Genomics Screening to Identify Potentially Novel Drug Targets in Cancer Cell Spheroid Cultures
07:48

Utilizing Functional Genomics Screening to Identify Potentially Novel Drug Targets in Cancer Cell Spheroid Cultures

Published on: December 26, 2016

11.5K
Extraction of Aqueous Metabolites from Cultured Adherent Cells for Metabolomic Analysis by Capillary Electrophoresis-Mass Spectrometry
11:39

Extraction of Aqueous Metabolites from Cultured Adherent Cells for Metabolomic Analysis by Capillary Electrophoresis-Mass Spectrometry

Published on: June 9, 2019

9.2K

Area of Science:

  • Oncology
  • Biochemistry
  • Cancer Biology

Background:

  • Otto Warburg pioneered cancer metabolism research in the 1920s, noting glucose to lactate conversion in tumors.
  • Oncogenes, like MYC, regulate metabolic pathways essential for cancer cell growth and proliferation.
  • Tumor cells exhibit nutrient addiction, making them susceptible to deprivation-induced death.

Purpose of the Study:

  • To review historical and current opportunities and challenges in targeting cancer metabolism.
  • To explore the convergence of cancer cell metabolism and immunometabolism.
  • To understand the tumor metabolic microenvironment's impact on anti-tumor T cells and immunotherapy.

Main Methods:

  • Literature review of historical and contemporary research on cancer metabolism.
  • Analysis of oncogene-driven metabolic alterations in cancer.
  • Examination of the tumor microenvironment's metabolic landscape.

Main Results:

  • Targeting cancer metabolism for therapy has faced commercial setbacks despite initial promise.
  • Cancer cell metabolism significantly influences the tumor microenvironment and immune cell function.
  • Tumor metabolic vulnerabilities are increasingly recognized as critical for therapeutic strategies.

Conclusions:

  • Despite past challenges, targeting cancer metabolism remains a vital area for therapeutic development.
  • Integrating cancer metabolism and immunometabolism research offers new avenues for cancer treatment.
  • Understanding tumor metabolic vulnerabilities is key to overcoming resistance to therapies, including immunotherapy.