Related Experiment Video
Updated: Sep 12, 2025
07:40
A Model of Self-limited Acute Lung Injury by Unilateral Intra-bronchial Acid Instillation
Published on: August 30, 2019
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Regulated programmed cell death in acute lung injury: from pathogenesis to therapy
Shi-Wen Liu1,2, Yi-Jian Chen1,2, Yi Liu3
1Department of Anesthesiology, Ganzhou People's Hospital, Ganzhou, Jiangxi, China.
Frontiers in Immunology
|August 7, 2025
Summary
Regulated programmed cell death (RCD) plays a critical role in acute lung injury (ALI). Understanding RCD mechanisms in ALI offers new therapeutic targets for this severe lung condition.
Area of Science:
- Pulmonary Medicine
- Cell Biology
- Pathophysiology
Background:
- Acute lung injury (ALI) is a severe condition with high mortality, characterized by lung inflammation.
- Abnormally advanced regulated programmed cell death (RCD) is a key pathological process in ALI.
- Various RCD types, including apoptosis, pyroptosis, necroptosis, ferroptosis, and autophagy, are implicated.
Purpose of the Study:
- To review the roles and mechanisms of different RCD types in ALI.
- To explore the associations among various RCD types in the context of ALI.
- To identify potential molecular targets for ALI treatment.
Main Methods:
- Literature review of studies on RCD and ALI.
- Analysis of molecular mechanisms underlying RCD in ALI.
- Discussion of interconnections between different RCD pathways.
Main Results:
- RCD is an active, gene-expression-mediated process crucial for cell elimination and defense.
- Specific RCD pathways are significantly involved in ALI pathogenesis.
- Interactions between different RCD types influence ALI progression.
Conclusions:
- Understanding RCD in ALI enhances knowledge of its pathophysiology.
- Targeting RCD pathways may offer novel therapeutic strategies for ALI.
- Further research into RCD mechanisms can aid in treating ALI of unknown etiology.
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