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Updated: Sep 12, 2025

Remote Laboratory Management: Respiratory Virus Diagnostics
Published on: April 6, 2019
Hotels as quarantine facilities with airborne virus controls
Hamed Sobhani1, Shengwei Zhu1, Jelena Srebric1
1Department of Mechanical Engineering, University of Maryland, College Park, MD, USA.
This study introduces an air-cleaning strategy using a validated model for quarantine hotels to control viral aerosol transmission. The best strategy significantly reduced infection risk, proving crucial for pandemic public health measures.
Area of Science:
- Environmental Health Engineering
- Infectious Disease Control
- Building Science
Background:
- Hotels repurposed as quarantine facilities during COVID-19 often lacked effective air-cleaning systems.
- Viral aerosol transmission, particularly between zones, posed a significant risk to quarantine effectiveness.
- Controlling inter-zonal transmission is critical for isolating infected individuals in shared facilities.
Purpose of the Study:
- To design and evaluate effective air-cleaning strategies for quarantine hotels.
- To assess strategies for minimizing viral aerosol transmission, especially between different zones.
- To develop an index for evaluating the performance of air-cleaning infrastructure.
Main Methods:
- Development of a validated multi-zone model of an actual quarantine hotel.
- Introduction and application of the inter-zonal air exchange rate (zACH) index.
- Evaluation of various air-cleaning strategies, including UVGI, HEPA filters, air curtains, and combined approaches.
Main Results:
- The inter-zonal air exchange rate (zACH) significantly improved with air-cleaning strategies.
- Individual air-cleaning devices (UVGI, HEPA, air curtains) yielded zACH values of 3.5, 2.8, and 1.7 1/h, respectively.
- The optimal combined strategy achieved a zACH of 8.5 1/h, reducing maximum infectious exposure risk to below 0.4% in rooms and 1.6% in corridors.
Conclusions:
- A comprehensive air-cleaning strategy can effectively mitigate viral aerosol transmission in quarantine hotels.
- Optimizing air-cleaning requires balancing effectiveness with cost and energy considerations, as performance is not linear with device count.
- The findings provide a framework for improving infection control in quarantine settings and inform future pandemic mitigation efforts.
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