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Nontraditional Risk Factors for Peripheral Artery Disease: Setting the Scene
Matthew Allison1, Janet T Powell2, Jonathan Golledge3
1Division of Preventive Medicine, Department of Family Medicine, University of California San Diego, La Jolla (M.A.A.).
Peripheral artery disease (PAD) affects 6% of adults, leading to poor quality of life and increased mortality. This review introduces PAD, focusing on traditional risk factors and setting the stage for exploring nontraditional factors to improve patient outcomes.
Area of Science:
- Vascular Medicine
- Cardiovascular Research
- Public Health
Background:
- Peripheral artery disease (PAD) affects 6% of adults, causing significant morbidity and mortality.
- PAD is understudied compared to coronary artery disease, despite similar risk factors.
- Understanding PAD is crucial for improving patient quality of life and reducing adverse events.
Purpose of the Study:
- Introduce the population burden, pathophysiology, and traditional risk factors of PAD.
- Serve as an introduction to a series of reviews on nontraditional risk factors for PAD.
- Highlight planned reviews to address unmet needs in PAD management.
Main Methods:
- Literature review and synthesis of existing data on PAD.
- Comparative analysis of PAD and coronary artery disease risk factors.
- Introduction to a planned series of focused reviews.
Main Results:
- PAD affects 6% of adults, impacting quality of life and survival.
- Traditional risk factors for PAD are discussed.
- Differences in risk factors between PAD and coronary artery disease are noted.
Conclusions:
- PAD requires further investigation, particularly regarding nontraditional risk factors.
- Addressing unmet needs in PAD is essential for improving patient outcomes.
- This series aims to advance understanding and management of PAD.
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