^99mTc-SNW-1 Nanoparticle Labeling and Its Biodistribution/Pathological Evaluations

Area of Science:

• Nanotechnology
• Radiopharmacology
• Biomedical Imaging

Background:

• Nanoparticles offer versatile platforms for diagnostic imaging and targeted therapies.
• Evaluating the in vivo behavior of novel nanoparticles is crucial for their clinical translation.

Purpose of the Study:

• To synthesize and characterize SNW-1 nanoparticles.
• To assess the diagnostic imaging and therapeutic potential of SNW-1 nanoparticles.
• To evaluate the in vivo biodistribution of SNW-1 nanoparticles.

Main Methods:

• Microwave-assisted synthesis of SNW-1 nanoparticles.
• Characterization of nanoparticle size, zeta potential, morphology, and chemical structure.
• Technetium-99m labeling of nanoparticles for in vivo biodistribution studies in rabbits and rats.

Main Results:

• Quasispherical SNW-1 nanoparticles (370.4 nm, zeta potential 0.4 mV) were successfully synthesized.
• In rabbits, highest nanoparticle accumulation was observed in the bladder, followed by liver, kidney, and heart.
• In rats, the liver showed the highest accumulation, followed by the bladder and heart.

Conclusions:

• SNW-1 nanoparticles exhibit high bladder accumulation, suggesting rapid clearance.
• The biodistribution profile makes SNW-1 nanoparticles promising for kidney imaging and therapeutic applications.
• Further research is warranted to explore their full clinical potential.