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Registered Bioimaging of Nanomaterials for Diagnostic and Therapeutic Monitoring
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99mTc-SNW-1 Nanoparticle Labeling and Its Biodistribution/Pathological Evaluations.

Setareh Derakhshan1, Mehdi Shafiee Ardestani1, Tahereh Zadeh Mehrizi2

  • 1Department of Radiopharmacy, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran.

Journal of Labelled Compounds & Radiopharmaceuticals
|August 7, 2025
PubMed
Summary

SNW-1 nanoparticles show high accumulation in the bladder, indicating efficient clearance for potential kidney imaging and therapeutic uses. This study details their synthesis and biodistribution in animal models.

Keywords:
Schiff Base Network 1covalent organic frameworkmolecular imagingsingle‐photon emission computed tomography

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Area of Science:

  • Nanotechnology
  • Radiopharmacology
  • Biomedical Imaging

Background:

  • Nanoparticles offer versatile platforms for diagnostic imaging and targeted therapies.
  • Evaluating the in vivo behavior of novel nanoparticles is crucial for their clinical translation.

Purpose of the Study:

  • To synthesize and characterize SNW-1 nanoparticles.
  • To assess the diagnostic imaging and therapeutic potential of SNW-1 nanoparticles.
  • To evaluate the in vivo biodistribution of SNW-1 nanoparticles.

Main Methods:

  • Microwave-assisted synthesis of SNW-1 nanoparticles.
  • Characterization of nanoparticle size, zeta potential, morphology, and chemical structure.
  • Technetium-99m labeling of nanoparticles for in vivo biodistribution studies in rabbits and rats.

Main Results:

  • Quasispherical SNW-1 nanoparticles (370.4 nm, zeta potential 0.4 mV) were successfully synthesized.
  • In rabbits, highest nanoparticle accumulation was observed in the bladder, followed by liver, kidney, and heart.
  • In rats, the liver showed the highest accumulation, followed by the bladder and heart.

Conclusions:

  • SNW-1 nanoparticles exhibit high bladder accumulation, suggesting rapid clearance.
  • The biodistribution profile makes SNW-1 nanoparticles promising for kidney imaging and therapeutic applications.
  • Further research is warranted to explore their full clinical potential.