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Related Concept Videos

Attention-Deficit/Hyperactivity Disorder01:30

Attention-Deficit/Hyperactivity Disorder

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Attention-deficit/hyperactivity disorder (ADHD) is a neurodevelopmental disorder characterized by persistent inattention, hyperactivity, and impulsivity. It affects approximately 5-8% of children globally, with around 60-70% of cases persisting into adulthood. ADHD has significant implications for educational attainment, social interactions, and occupational success.
Diagnostic Criteria and Symptoms
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Human genetics provides a profound framework for understanding the interplay between genetic predispositions and human psychology. At the heart of this discipline lies the study of how genes influence physical traits, behaviors, and susceptibility to diseases. Each person carries a unique genetic code that subtly or significantly shapes their psychological and behavioral landscape.
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Related Experiment Video

Updated: Sep 12, 2025

Event Related Potentials ERPs and other EEG Based Methods for Extracting Biomarkers of Brain Dysfunction: Examples from Pediatric Attention Deficit/Hyperactivity Disorder ADHD
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Multinutrients Decrease Oxidative Stress in Children With ADHD: Mediation/Moderation Analysis of Randomized

Lisa M Robinette1, Irene E Hatsu1,2, Olorunfemi Adetona3

  • 1Department of Human Sciences, The Ohio State University, Columbus, OH, USA.

Journal of Attention Disorders
|August 7, 2025
PubMed
Summary
This summary is machine-generated.

Multinutrient supplementation for ADHD in children reduced oxidative stress markers, specifically reactive oxygen metabolites (ROM), over eight weeks. This suggests a potential link between nutrient intake and reduced oxidative stress in ADHD, warranting further investigation.

Keywords:
ADHDRCTantioxidantchildrenglutathionemultinutrientoxidative stresssupplement

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Area of Science:

  • Nutritional Psychiatry
  • Biochemistry
  • Pediatric Neurology

Background:

  • Attention-Deficit/Hyperactivity Disorder (ADHD) is linked to oxidative stress (OS), potentially due to nutrient deficiencies.
  • Previous trials showed multinutrient supplements improved ADHD symptoms.
  • The impact of multinutrients on antioxidant status and OS in ADHD remains unclear.

Purpose of the Study:

  • To compare changes in antioxidant (AO) and OS biomarkers after 8-week multinutrient supplementation versus placebo in children with ADHD.
  • To assess if baseline AO/OS biomarkers and their changes moderate or mediate treatment response.

Main Methods:

  • Analysis of plasma samples from the Micronutrients for ADHD in Youth (MADDY) RCT.
  • Measurement of glutathione peroxidase (GPx), glutathione reductase (GR), oxidative stress index (OSI), reactive oxygen metabolites (ROM), and biological antioxidant potential (BAP) at baseline and 8 weeks.
  • Statistical comparison using t-tests/Mann-Whitney U-test and logistic regression for mediation/moderation analysis.

Main Results:

  • Seventy-seven children (9.9 ± 1.7 years, 71% male) were analyzed.
  • Multinutrient treatment significantly decreased ROM compared to placebo after 8 weeks (p=0.017).
  • No significant differences were found in OSI, BAP, GPx, or GR between groups; baseline biomarkers did not moderate response, and changes in OSI/ROM showed non-significant trends toward mediation.

Conclusions:

  • Eight weeks of multinutrient supplementation reduced ROM in children with ADHD, indicating a potential decrease in oxidative stress.
  • While antioxidant status did not change significantly, the preliminary findings suggest a link between reduced OS and symptom improvement, meriting further research into OS in ADHD pathogenesis.