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Biomedical and Clinical Sciences
Oncology and Carcinogenesis
Predictive and prognostic markers
Letter: Dynamic Tumor in Situ Fluid Circulating Tumor DNA Post Surgery Effectively Predicts Recurrence and Clinical Benefits for Glioblastomas

Letter: Dynamic Tumor in Situ Fluid Circulating Tumor DNA Post Surgery Effectively Predicts Recurrence and Clinical Benefits for Glioblastomas

Laiba Azhar ¹, Bibha Osti ², M Marzia Noor ³, Md Moshiur Rahman ⁴

Laiba Azhar ¹, Bibha Osti ², M Marzia Noor ³

¹Liaquat National Hospital and Medical College, Karachi, Pakistan.
²Spinal Injury Rehabilitation Center - Nepal, Sanga, Nepal.
³Central Medical College and Hospital, Dhaka, Bangladesh.
⁴Neurosurgery Department, Holy Family Red Crescent Medical College, Dhaka, Bangladesh.

⁰Liaquat National Hospital and Medical College, Karachi, Pakistan.

Neurosurgery +

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August 7, 2025

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August 7, 2025

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Summary

No abstract available on PubMed

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Tumor Progression

Tumor Progression

Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...

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