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Updated: Sep 12, 2025

A Preclinical Model of Exertional Heat Stroke in Mice
Published on: July 1, 2021
[Heatstroke]
Christophe Bianchi1,2, Laurent Vallotton1, Pierre-Nicolas Carron1
1Service des Urgences, Centre Hospitalier Universitaire Vaudois, Lausanne.
Introduction:
Heat stroke is a serious and underdiagnosed condition, which is subdivided into exercise and classic subtypes. Climate change and increasing temperatures are making this pathology more and more common. Its pathophysiology is closely linked to the ability of the cardiovascular system to adapt. Multi-organ damage can complicate this disease, through a systemic inflammatory response. Acute neurological symptoms and signs are the typical clinical presentation of heatstroke. Management is based on early and active cooling, as well as support for vital functions. Preventing this problem requires a community and public health response.
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