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Multifunctional nanoparticles in endodontics: applications, challenges, and future directions.
Una Ivković1, Catalina Moreno-Rabié1,2, Arn Mignon3
1OMFS-IMPATH Research Group, Department of Imaging and Pathology, Faculty of Medicine, University of Leuven, Leuven, Belgium.
Discover Nano
|August 7, 2025
Summary
Nanoparticles show promise in endodontics for tissue regeneration and material enhancement. Inorganic nanoparticles dominate research, but organic options like chitosan are relevant for carriers and therapeutics.
Area of Science:
- Biomaterials Science
- Dental Research
- Nanotechnology
Background:
- Nanoparticles offer novel solutions for the dentin-pulp complex in endodontics.
- Challenges in endodontic treatment necessitate advanced material applications.
Purpose of the Study:
- To review multifunctional nanoparticle applications in endodontics.
- Focus on therapeutic effects, material enhancement, and carrier functions.
Main Methods:
- Scoping review following PRISMA-Scoping guidelines.
- Searched Web of Science, PubMed, and Scopus.
- Included 70 studies after screening 490 articles.
Main Results:
- Inorganic nanoparticles (77%) dominate over organic (23%).
- Chitosan (29%) and extracellular vesicles (22%) are key organic materials.
- Bioactive glass is prominent among inorganic materials for various applications.
Conclusions:
- Nanoparticles enhance antibacterial efficacy and bioactivity in endodontics.
- Challenges include biocompatibility, scalability, and clinical integration.
- Translational research is crucial for clinical application.
