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Hallucinogens and Psychedelics01:27

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Hallucinogens are psychoactive substances that profoundly alter perceptual experiences, generating unreal visual and sensory images. Often referred to as psychedelic drugs — a term derived from the Greek words "psyche" (mind) and "delos" (revealing) — these substances include marijuana and lysergic acid diethylamide (LSD), among others. These drugs vary in intensity and effects.
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Hallucinogens, also known as psychedelic drugs, are a class of substances known for their ability to alter perception, cognition, and emotions. Despite their profound effects on the mind, these drugs are non-addictive, setting them apart from many other abused substances. The mechanism of action of these drugs lies in their impact on the 5-HT2A receptor in the brain. Upon activation, this receptor couples to Gq-type G proteins, triggering a cascade that releases intracellular calcium. This...
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Ethical Issues and Recommendations in Psychedelic Research and Practice: A Scoping Review.

N Brittain1, N Higgins2, M Barber2

  • 1School of Psychological Sciences, Monash University, 770 Blackburn Rd, Clayton Melbourne, VIC, 3800, Australia. noa.brittain@gmail.com.

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|August 7, 2025
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Summary

Psychedelic research presents ethical challenges. This review identifies key issues like practice standards and equity, while also highlighting neglected areas such as post-trial care and practitioner training.

Keywords:
Cultural appropriationEquityEthicsJusticePsychedelic researchPsychedelic-assisted therapy

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Area of Science:

  • Psychiatry
  • Neuroscience
  • Bioethics

Background:

  • The resurgence of psychedelic research and therapy introduces complex ethical considerations.
  • A lack of consensus exists among stakeholders regarding the management of these ethical challenges.

Purpose of the Study:

  • To systematically identify and analyze the ethical issues present in psychedelic research and clinical practice.
  • To highlight areas requiring further attention and development in the field.

Main Methods:

  • A comprehensive scoping review of fifty-one relevant articles was conducted.
  • Content analysis was employed to categorize identified ethical concerns.
  • A consultation workshop was held to gather expert insights on neglected ethical issues.

Main Results:

  • Five primary ethical concerns emerged from the literature: standards of practice, equity, integrity, cultural appropriation, and epistemic justice.
  • Key neglected issues included post-trial care, consensus on care models and practitioner competencies, and translation of research ethics into practice.

Conclusions:

  • Clear competency frameworks and guidelines for Indigenous recognition are needed.
  • Enhanced consultation with diverse populations and robust governance for psychedelic prescribing are recommended.
  • Addressing post-trial care and standardizing models of care are crucial for ethical psychedelic practice.