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A novel marker for determining the severity of coronary artery disease: the metabolic coronary risk index

Yücel Kanal1, Idris Yakut2

  • 1Cumhuriyet University, Department of Cardiology, Turkey.

Cardiovascular Journal of Africa
|August 7, 2025
PubMed

Insights

The metabolic coronary risk index (MCRI) effectively predicts coronary artery disease (CAD) severity in acute coronary syndrome (ACS) patients. This finding aids in assessing cardiovascular risk and guiding treatment strategies for CAD.

Area of Science:

  • Cardiology
  • Metabolic Syndrome
  • Clinical Risk Assessment

Background:

  • Coronary artery disease (CAD) is a leading global cause of mortality despite advancements.
  • Glycated haemoglobin (HbA1c) and body mass index (BMI) are established CAD risk factors.
  • Predictive markers for CAD severity are crucial for patient management.

Purpose of the Study:

  • To evaluate the association between the metabolic coronary risk index (MCRI) and CAD severity.
  • To determine if MCRI can predict the SYNTAX score (SS) in patients with acute coronary syndrome (ACS).

Main Methods:

  • A cohort of 214 patients with ACS undergoing coronary angiography (CAG) was analyzed.
  • Regression analysis was employed to assess the predictive value of MCRI for CAD severity (SYNTAX score).
  • Sensitivity and specificity of MCRI for differentiating SS grades were calculated.

Main Results:

  • MCRI was identified as an independent predictor of CAD severity.
  • A cutoff value of 158.9 for MCRI demonstrated 70% sensitivity and 50% specificity in distinguishing moderate/high SS from low SS.
  • The study included a diverse patient population with a mean age of 59.29 years.

Conclusions:

  • MCRI is a significant and independent predictor of coronary artery disease severity in ACS patients.
  • MCRI can assist in stratifying patients based on CAD complexity.
  • Further research may explore MCRI's role in guiding therapeutic decisions for ACS.

Keywords:
HbA1cacute coronary syndromebody mass indexcoronary artery diseasepercutaneous coronary intervention

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