Improving Alzheimer's disease immunotherapy

Mengen Xing1, Weihong Song1,2

  • 1Center for Geriatric Medicine, International Center for Alzheimer's Research, Prevention and Treatment, The First Affiliated Hospital and Oujiang Laboratory; Key Laboratory of Alzheimer's Disease of Zhejiang Province, Institute of Aging, Wenzhou Medical University, Wenzhou, Zhejiang, China.

Science (New York, N.Y.)
|August 7, 2025
PubMed
Abstract

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Alzheimer's Disease (AD), a neurodegenerative disorder, is pathologically identified by amyloid plaques and neurofibrillary tangles composed of tau protein. AD pharmacotherapy aims to manage cognitive symptoms, delay disease progression, and treat behavioral symptoms. The treatment is primarily symptomatic and palliative, with no definitive disease-modifying therapy available. Cholinesterase inhibitors, including donepezil (Aricept), rivastigmine (Exelon), and galantamine (Razadyne), are...
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