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Related Concept Videos

Drug Delivery: Overview01:16

Drug Delivery: Overview

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The selection of a drug's delivery route depends upon its physicochemical properties, including lipid or water solubility and ionization, as well as the therapeutic requirement, such as immediate or sustained effect. These routes can be divided into three primary categories: enteral, parenteral, and topical.
Enteral delivery involves administering drugs directly through swallowing, sublingual placement, or buccal application. Orally administered drugs predominantly navigate the...
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Chronopharmacokinetics studies the temporal change in drug absorption and elimination. These changes can be cyclical or non-cyclical. Cyclical changes occur over a regular interval, while non-cyclical changes occur over a longer, irregular period.
Time-dependent pharmacokinetics refers to non-cyclical changes in drug rate processes over a period of time. It can lead to nonlinear pharmacokinetics, where the relationship between drug concentration and time is not proportional. Non-cyclical...
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Drug delivery methods like oral inhalation, nasal sprays, transdermal patches, eye drops, intravitreal injection,  and rectal administration provide localized effects with reduced toxicity.
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Circadian rhythms are cyclic changes that are crucial in plasma drug concentrations. Various standard circadian parameters, including core body temperature, heart rate, and other cardiovascular factors, directly impact disease states and the therapeutic response to drug therapy.
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Updated: Sep 12, 2025

Alternating Magnetic Field-Responsive Hybrid Gelatin Microgels for Controlled Drug Release
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Janus acoustically responsive scaffolds for sequential drug release with phase-programmed steady and pulsatile

Haijun Xiao1, Somnath Maji1, Abigail Pinch2

  • 1Department of Radiology, University of Michigan, Ann Arbor, 48109, MI, USA.

Journal of Colloid and Interface Science
|August 7, 2025
PubMed
Summary

This study introduces a Janus acoustically responsive scaffold (ARS) for controlled sequential drug delivery. The novel hydrogel system uses ultrasound to trigger distinct release profiles, offering advanced therapeutic solutions.

Keywords:
Acoustic droplet vaporizationFibrin hydrogelKineticsPerfluorocarbonPulsatile releaseSequential releaseUltrasoundZero order release

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Area of Science:

  • Biomaterials Science
  • Drug Delivery Systems
  • Acoustic Engineering

Background:

  • Precise temporal control of drug release, including sequential delivery with varied profiles, is vital for effective therapy.
  • Current systems struggle to achieve sequential release with distinct kinetics like steady and pulsatile profiles.

Purpose of the Study:

  • To develop a novel Janus acoustically responsive scaffold (ARS) for precisely controlled sequential drug release using ultrasound.
  • To demonstrate the capability of the ARS to combine distinct release kinetics (steady and pulsatile) for dual-payload delivery.

Main Methods:

  • Fabrication of a Janus ARS composite hydrogel containing fibrin and phase-shift emulsions (perfluorohexane or perfluorooctane).
  • Utilized ultrasound-triggered acoustic droplet vaporization (ADV) to induce bubble formation and drug release.
  • Characterized release kinetics, morphological changes, and developed quantitative release models.

Main Results:

  • ARS with perfluorohexane emulsion showed triphasic release and steady delivery over days.
  • ARS with perfluorooctane emulsion exhibited biphasic release with macropore formation and pulsatile delivery.
  • Successfully achieved sequential release of two payloads by exploiting frequency-dependent ADV behavior.

Conclusions:

  • The Janus ARS platform enables sophisticated temporal drug presentation with distinct release profiles.
  • This technology offers advanced drug delivery solutions for complex therapeutic challenges unmet by conventional systems.
  • Validated quantitative models support the predictable performance of the Janus ARS for drug delivery.