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Developmental Trajectories of Adaptive Functioning and Behavior Problems in Children With Co-Occurring Tuberous
Lynnel C Goodman1, Melissa A Richard2, John P Woodhouse2
1Louis A. Faillace, MD Department of Psychiatry and Behavioral Sciences, McGovern Medical School, The University of Texas Health Science Center at Houston (UT Health), Houston, Texas; Center for Depression Research and Clinical Care, Peter O'Donnell Jr. Brain Institute and the Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, Texas.
Pediatric Neurology
|August 7, 2025
Summary
Children with tuberous sclerosis complex (TSC) and autism spectrum disorder (ASD) show poorer social and emotional development by 36 months. Early detection of developmental concerns in TSC with ASD is crucial for targeted interventions.
Area of Science:
- Neurodevelopmental disorders
- Pediatric neurology
- Developmental psychology
Background:
- Tuberous sclerosis complex (TSC) increases risks for adaptive and behavioral issues, including autism spectrum disorder (ASD).
- Understanding developmental trajectories in children with TSC, with and without ASD, is critical.
Purpose of the Study:
- To evaluate the adaptive and behavioral developmental trajectories of children with TSC.
- To compare children with TSC with and without an ASD diagnosis at 36 months.
Main Methods:
- Longitudinal assessment of infants with TSC using Mullen Scales of Early Learning, Vineland Adaptive Behavior Scales, and Child Behavior Checklist.
- Analysis of functioning at 18, 24, and 36 months in relation to ASD diagnosis at 36 months.
Main Results:
- Children with TSC and eventual ASD diagnosis showed adaptive deficits from 18 months, particularly in social functioning by 36 months.
- Behavioral and emotional problems were more severe in children with TSC and ASD by 36 months, even after adjusting for developmental level.
- Seizure burden did not explain these observed differences.
Conclusions:
- Children with TSC and ASD demonstrated significantly poorer social adjustment and emotional/behavioral functioning by 36 months compared to peers without ASD.
- Early identification of developmental concerns in this population is vital.
- Targeted treatments are essential for improving outcomes in children with TSC and ASD.
Keywords:
Child Behavior Checklist (CBCL)Infant developmentSocioemotionalTuberous sclerosis complex (TSC)TubersVineland Adaptive Behavior Scales (VABS-II)More Related Videos
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