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Related Concept Videos

Targeted Cancer Therapies02:57

Targeted Cancer Therapies

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The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
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Treatment Resistant Cancers02:56

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Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
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Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
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Updated: Sep 12, 2025

Author Spotlight: Advancements in Molecular Biomarker Testing for Non-Squamous Non-Small Cell Lung Cancer
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Author Spotlight: Advancements in Molecular Biomarker Testing for Non-Squamous Non-Small Cell Lung Cancer

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Small-Cell Lung Cancer Updates.

Yunan Nie1, Anne C Chiang1

  • 1Division of Thoracic Medical Oncology, Department of Medicine, Yale School of Medicine, New Haven, Connecticut.

Seminars in Respiratory and Critical Care Medicine
|August 7, 2025
PubMed
Summary
This summary is machine-generated.

Small-cell lung cancer (SCLC) treatment is rapidly evolving with new chemoimmunotherapy options. Despite improved survival rates, most patients still face disease progression, highlighting an ongoing need for better therapies.

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Area of Science:

  • Oncology
  • Pulmonology
  • Medical Oncology

Background:

  • Small-cell lung cancer (SCLC) is an aggressive neuroendocrine tumor with a poor prognosis and limited treatment options.
  • Advanced SCLC, diagnosed in 70% of patients, historically has a 5-year survival rate below 5%.
  • Therapy resistance and early metastasis are hallmarks of SCLC, contributing to its challenging nature.

Purpose of the Study:

  • To review current standard of care for SCLC.
  • To highlight recent advances and promising clinical trials in SCLC treatment.
  • To discuss improvements in outcomes and survival for SCLC patients.

Main Methods:

  • Review of recent clinical trials and therapeutic approvals for SCLC.
  • Analysis of first-line, second-line, and consolidative treatment strategies.
  • Focus on the impact of immunotherapy and novel agents in SCLC management.

Main Results:

  • First-line treatment for advanced SCLC now combines chemotherapy and immunotherapy.
  • Consolidative immunotherapy after chemoradiation significantly improves survival in early-stage SCLC.
  • Recent trials show 3-year survival rates of 16-17% for advanced SCLC with chemoimmunotherapy.

Conclusions:

  • SCLC treatment has advanced significantly with new approvals and improved survival.
  • Despite progress, rapid disease progression after first-line therapy remains a challenge.
  • Further research is crucial to address the unmet needs in SCLC management.