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Updated: Sep 12, 2025

ATAC-Seq Library Preparation of Murine Bone Marrow-Derived Neutrophils
Published on: January 3, 2025
Ontogenetic drivers of neutrophil heterogeneity
Ali Hageb1, Merieme Farjia1, Collins Osei-Sarpong1
1Institute of Experimental Pathology (ExPat), Center for Molecular Biology of Inflammation (ZMBE), University of Münster, Münster, Germany.
Abstract:
Neutrophil development is a tightly regulated, multistep process involving stem cell commitment, differentiation, and maturation in the bone marrow. Chromatin remodeling, transcriptional networks, epigenetic reprogramming, metabolic adaptations, and structural changes collectively govern neutrophil production, shaping both maturation states and functional potential. Although these processes can be leveraged to adapt the neutrophil pool quantitatively and qualitatively during homeostasis or inflammatory stress, their dysregulation often drives disease progression. In this review, we examine how these ontogenetic factors specify neutrophil functions and underscore the significance of functional diversity across different maturation states.
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