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Updated: Sep 12, 2025

Author Spotlight: High-Sensitivity Tissue Factor Activity Assay for Plasma Diagnosis
Published on: December 29, 2023
The role of tissue factor in the tumor microenvironment and targeted therapy
Ying Yan1, Yifan Li1, Dan Zou1
1The Second Hospital and Clinical Medical School, Lanzhou University, Lanzhou, China; Key Laboratory of the Digestive System Tumors of Gansu Province, The Second Hospital and Clinical Medical School, Lanzhou, China.
Abstract:
Tissue factor (TF) serves as a pivotal initiator of coagulation and has been extensively acknowledged for its substantial involvement in cancer progression and metastasis. Recent evidence suggests that targeting TF can enhance the infiltration of immune effector cells, thereby reshape the tumor microenvironment (TME). Despite these advancements, a comprehensive review of TF's role within the TME has yet to be conducted. This review uniquely synthesizes emerging evidence on TF-mediated immunosuppression mechanisms and evaluates cutting-edge targeting strategies to overcome therapy resistance.
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