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Updated: Sep 12, 2025

Adoptive Immunotherapy of iNKT Cells in Glucose-6-Phosphate Isomerase G6PI-Induced RA Mice
Published on: January 31, 2020
Immune checkpoint inhibitor-induced inflammatory arthritis
Benjamin A Fisher1, Andrew Allard2, Shirish Dubey3
1Rheumatology Research Group, Department of Inflammation and Ageing, School of Infection, Inflammation and Immunology, University of Birmingham, Birmingham, UK; Department of Rheumatology and NIHR Birmingham Biomedical Research Centre, University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK.
Abstract:
Immune checkpoint inhibitors (ICI) used for the treatment of malignancy are associated with immune-related adverse events, which include inflammatory arthritis. ICI-induced inflammatory arthritis (ICI-IA) is a new clinical entity that may lead to functional impairment and may be persistent even after ICI cessation. We discuss the clinical features, investigation and differential diagnosis. Management needs to consider the safety of immunosuppression in the context of the underlying cancer, and current practice will be further informed by ongoing clinical trials.
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