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Published on: January 31, 2020
Immune checkpoint inhibitor-induced inflammatory arthritis
Benjamin A Fisher1, Andrew Allard2, Shirish Dubey3
1Rheumatology Research Group, Department of Inflammation and Ageing, School of Infection, Inflammation and Immunology, University of Birmingham, Birmingham, UK; Department of Rheumatology and NIHR Birmingham Biomedical Research Centre, University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK.
Immune checkpoint inhibitors (ICI) can cause immune-related adverse events like inflammatory arthritis (IA). This new entity, ICI-induced IA, may persist and cause functional impairment, requiring careful management strategies.
Area of Science:
- Oncology
- Rheumatology
- Immunology
Background:
- Immune checkpoint inhibitors (ICIs) are crucial cancer therapies.
- ICIs can trigger immune-related adverse events (irAEs).
- Inflammatory arthritis (IA) is a recognized irAE associated with ICIs.
Purpose of the Study:
- To describe the clinical features of ICI-induced IA.
- To outline diagnostic investigations and differential diagnoses for ICI-IA.
- To discuss management strategies for ICI-IA.
Main Methods:
- Review of clinical features.
- Discussion of diagnostic approaches.
- Analysis of management considerations.
Main Results:
- ICI-IA presents as a distinct clinical entity.
- Functional impairment and persistence are potential characteristics of ICI-IA.
- Management requires balancing immunosuppression with cancer treatment needs.
Conclusions:
- ICI-IA is an emerging clinical challenge.
- Further research and clinical trials are needed to refine management.
- Careful consideration of immunosuppression is vital for patients with cancer.
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