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Updated: Sep 12, 2025

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Porcine Liver Transplantation Without Veno-Venous Bypass As an Extended Criteria Donor Model
Published on: August 17, 2022
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Guidance for Timely Referral to Liver Transplantation
Lindsay Y King1, Elizabeth S Aby2, Archita Desai3
1Department of Medicine, Duke University School of Medicine, Durham, North Carolina.
Summary
Timely referral for liver transplantation (LT) is crucial for patients with advanced liver disease. Early identification and referral improve outcomes and access to specialized care, preventing loss of the LT window.
Area of Science:
- Hepatology
- Transplant Surgery
- Gastroenterology
Background:
- Cirrhosis-related morbidity and mortality are rising, primarily due to liver decompensation.
- Liver transplantation (LT) offers the only cure for decompensated cirrhosis and certain liver complications.
- Delayed or missed LT referrals negatively impact patient quality of life and increase mortality.
Purpose of the Study:
- To provide guidance to adult healthcare providers on timely LT referral.
- To clarify the LT evaluation process and identify contraindications.
- To foster collaboration between referring providers and transplant centers for advanced liver disease patients.
Main Methods:
- Guidance document development for healthcare providers.
- Review of LT referral criteria and contraindications.
- Emphasis on multidisciplinary team involvement and provider education.
Main Results:
- Timely identification of LT candidates is essential to avoid missing the transplant window.
- Early referral ensures access to specialized multidisciplinary teams.
- Understanding the LT framework facilitates efficient patient management.
Conclusions:
- Optimizing LT referral pathways is critical for improving outcomes in advanced chronic liver disease.
- Enhanced provider education and collaboration are key to successful LT programs.
- Proactive management of LT candidates maximizes the benefits of this life-saving procedure.
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