Related Experiment Video
Updated: Sep 12, 2025
13:56
Robot Assisted Distal Pancreatectomy with Celiac Axis Resection DP-CAR for Pancreatic Cancer: Surgical Planning and Technique
Published on: August 14, 2021
6.5K
Peripancreatic Vascular Involvement and Gastric Varices in Autoimmune Pancreatitis: A Multicenter Retrospective Study
Noriko Juri1, Atsuhiro Masuda1, Ryota Nakano2
1Division of Gastroenterology, Department of Internal Medicine, Kobe University Graduate School of Medicine, Kobe, Japan.
Summary
Autoimmune pancreatitis (AIP) frequently causes vascular issues like splenic vein stenosis. Glucocorticoid therapy effectively treats these complications, reducing risks and improving patient outcomes.
Area of Science:
- Gastroenterology
- Vascular Medicine
- Immunology
Background:
- Autoimmune pancreatitis (AIP) can lead to peripancreatic vascular involvement, including portal system stenosis.
- This may result in collateral vessel formation and potentially life-threatening gastric varices.
- Current guidelines do not adequately address these vascular complications of AIP.
Purpose of the Study:
- To determine the frequency of vascular involvement in AIP patients.
- To assess the efficacy of glucocorticoid therapy on vascular complications.
- To identify key vessels associated with gastric varices in AIP.
Main Methods:
- A multicenter retrospective study of 230 AIP patients (2010-2021).
- Analysis of clinical data, contrast-enhanced CT scans, and endoscopy findings.
- Centralized evaluation of imaging by three specialists.
Main Results:
- 51.3% of patients had peripancreatic vascular involvement at diagnosis, mainly splenic vein stenosis (48.3%).
- Glucocorticoid therapy showed high response rates for venous stenosis (93.1%-95.6%) and collateral vessel improvement (80.9%).
- Gastric varices were associated with severe splenic vein stenosis.
Conclusions:
- Peripancreatic vascular involvement is a common complication of AIP.
- Vascular complications of AIP demonstrate significant response to glucocorticoid therapy.
- Close monitoring for vascular issues is crucial in AIP management to prevent severe outcomes.
Related Concept Videos
01:17Gastritis-II: Pathophysiology
548
Gastritis is marked by disruption of the mucosal barrier that usually protects the stomach tissue from digestive juices and manifests in acute and chronic forms.
In acute gastritis, the gastric mucosa becomes swollen and red and undergoes superficial erosion. Superficial ulceration may lead to bleeding.
In chronic gastritis, persistent or repeated insults lead to chronic inflammatory changes and, eventually, thinning or atrophy of the gastric tissue.
Gastritis can stem from various causes, each...
In acute gastritis, the gastric mucosa becomes swollen and red and undergoes superficial erosion. Superficial ulceration may lead to bleeding.
In chronic gastritis, persistent or repeated insults lead to chronic inflammatory changes and, eventually, thinning or atrophy of the gastric tissue.
Gastritis can stem from various causes, each...
548
01:24Chronic Pancreatitis I: Introduction
161
The pancreas, an elongated and flat gland situated behind the stomach, serves a vital function in digesting food and managing blood sugar levels.
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...
161
01:30Acute Pancreatitis II: Clinical Manifestations and Management
177
Acute pancreatitis presents a complex medical emergency characterized by rapid onset inflammation of the pancreas, demanding timely diagnosis and management to prevent complications. The condition primarily manifests through severe upper abdominal pain that often radiates to the back. This pain intensifies following the consumption of fatty foods. Accompanying symptoms such as nausea, vomiting, abdominal distention, fever, dyspnea, cyanosis, and jaundice can vary in intensity but significantly...
177
01:27Acute Pancreatitis I: Introduction
492
Pancreatitis is inflammation of the pancreas, an organ located behind the stomach. It can be either acute or chronic.
Acute pancreatitis is characterized by rapid inflammation of the pancreas, often caused by factors like gallstone blockage or excessive alcohol consumption. Chronic pancreatitis, on the other hand, is a slow, progressive inflammation that may result from long-term alcohol abuse, obstructions in the pancreatic duct, or genetic factors.
The causes of acute pancreatitis include:
Acute pancreatitis is characterized by rapid inflammation of the pancreas, often caused by factors like gallstone blockage or excessive alcohol consumption. Chronic pancreatitis, on the other hand, is a slow, progressive inflammation that may result from long-term alcohol abuse, obstructions in the pancreatic duct, or genetic factors.
The causes of acute pancreatitis include:
492
01:24Esophageal Varices-I: Introduction
338
Esophageal varices are dilated, tortuous veins which are found mainly in the submucosa of the lower esophagus but which may also appear higher up or extend into the stomach. They develop due to increased pressure in the portal venous system, often as a result of liver cirrhosis. This condition scars and damages the liver, impeding normal blood flow through the portal vein. To compensate, blood seeks alternative pathways, forming fragile new vessels (varices) in the esophagus and stomach. These...
338
01:27Gastritis-I: Introduction and Types
950
Gastritis, defined by the inflammation or irritation of the stomach lining or gastric mucosa, manifests in several distinct forms: acute, chronic, reactive, and a specific subtype known as autoimmune metaplastic atrophic gastritis.
Acute gastritis presents as a sudden inflammation triggered by various stressors to the stomach lining, such as exposure to corrosive agents, local irritants like aspirin and other NSAIDs, alcohol consumption, radiation therapy, physical trauma, severe burns, sepsis,...
Acute gastritis presents as a sudden inflammation triggered by various stressors to the stomach lining, such as exposure to corrosive agents, local irritants like aspirin and other NSAIDs, alcohol consumption, radiation therapy, physical trauma, severe burns, sepsis,...
950