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Prehabilitation: Cognitive considerations.

David P Sheppard1, Sarah P Psutka2, Hanna Hunter1

  • 1Department of Rehabilitation Medicine, University of Washington School of Medicine, Seattle, WA; Fred Hutchinson Cancer Center, Seattle, WA.

Urologic Oncology
|August 7, 2025
PubMed
Summary
This summary is machine-generated.

Cognitive dysfunction is common in urologic cancer survivors. This review explores prehabilitation strategies to support cognitive health before cancer treatment, aiming to improve quality of life.

Keywords:
CognitionCognitive rehabilitationNeuropsychological evaluationPerioperative

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Area of Science:

  • Oncology
  • Neuroscience
  • Rehabilitation Medicine

Background:

  • Urologic cancers and treatments can lead to cognitive dysfunction, impacting survivorship.
  • Current cognitive rehabilitation focuses on post-treatment compensatory strategies or restorative training.
  • Prehabilitation shows promise for urologic cancer outcomes but is understudied for cognitive function.

Purpose of the Study:

  • To review common cognitive deficits in urologic cancers.
  • To examine current cognitive rehabilitation evidence in cancer patients.
  • To identify potential prehabilitation approaches for cognitive support in urologic cancers.
  • To explore existing prehabilitation efforts (physical activity, nutrition, mood) applicable to cognitive endpoints.

Main Methods:

  • Literature review of studies on urologic cancers, cognitive dysfunction, and prehabilitation.
  • Analysis of cognitive rehabilitation strategies in broader cancer populations.
  • Identification of transferable prehabilitation interventions.

Main Results:

  • Cognitive dysfunction is a significant concern for urologic cancer survivors.
  • Evidence for cognitive rehabilitation exists but is primarily post-treatment.
  • Few studies have specifically investigated prehabilitation for cognitive function in urologic cancers.
  • Physical activity, nutrition, and mood interventions are established prehabilitation components with potential cognitive benefits.

Conclusions:

  • There is a need for cognitive prehabilitation in urologic cancer care.
  • A proposed model for cognitive prehabilitation can guide future research.
  • Integrating prehabilitation strategies may enhance cognitive resilience and outcomes for urologic cancer patients.