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[Multiple primary malignant melanomas].

H Schwanitz, L Suter

    Der Hautarzt; Zeitschrift Fur Dermatologie, Venerologie, Und Verwandte Gebiete
    |November 1, 1985
    PubMed
    Summary
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    This case study highlights a patient with multiple melanomas and lentigines malignae, primarily linked to prolonged sun exposure. Despite numerous tumors, the prognosis remains favorable, depending on the least aggressive lesion.

    Area of Science:

    • Dermatology
    • Oncology

    Background:

    • Melanoma and lentigo maligna are significant skin cancers.
    • Understanding risk factors and prognosis is crucial for patient management.

    Observation:

    • A 54-year-old woman developed 6 melanomas and 9 lentigines malignae over 5 years.
    • Five melanomas were classified as malignant lentigo melanomas.
    • Extensive, long-term sun exposure on the face, arms, and back was the sole identified risk factor.

    Findings:

    • The patient presented with multiple primary skin malignancies.
    • Prognosis is determined by the most unfavorable tumor, not the cumulative number of lesions.
    • The most advanced tumor measured 0.65 mm with level III invasion and a regression zone.

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    Implications:

    • This case underscores the importance of cumulative sun exposure as a risk factor for multiple melanomas.
    • It suggests that prognosis in patients with multiple melanomas may be influenced by the characteristics of the single most aggressive tumor.
    • Early detection and management of even less aggressive lesions are vital.