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Transcriptomic and functional analysis of triphenyl phosphate exposure in prostate cancer progression

  • 0Department of Anesthesiology, West China Hospital, School of Nursing, Sichuan University West China, Sichuan University, Chengdu, 610041, Sichuan Province, China.
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August 7, 2025

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August 7, 2025

View abstract on PubMed

Summary

This summary is machine-generated.

Triphenyl phosphate (TPP) exposure promotes prostate cancer cell growth and invasion by altering gene expression. This environmental pollutant may pose health risks, with identified genes serving as potential prognostic biomarkers for prostate cancer.

Area Of Science

  • Environmental toxicology
  • Cancer biology
  • Molecular oncology

Background

  • Prostate cancer is a prevalent malignancy with diverse clinical outcomes.
  • The influence of environmental chemicals, like Triphenyl phosphate (TPP), on prostate cancer progression is not well understood.
  • TPP is a common organophosphorus flame retardant used widely.

Purpose Of The Study

  • To investigate the effects of TPP exposure on gene expression in prostate cancer cells.
  • To identify TPP-associated genes and evaluate their prognostic significance.
  • To assess TPP-induced phenotypic changes in prostate cancer.

Main Methods

  • Transcriptomic profiling via mRNA sequencing to analyze gene expression changes.
  • Single-sample gene set enrichment analysis (ssGSEA) and Comparative Toxicogenomics Database (CTD) mining.
  • TCGA-based survival modeling and functional assays to assess prognostic relevance and phenotypic alterations.

Main Results

  • TPP exposure (0.1 µM) significantly increased prostate cancer cell proliferation and invasion.
  • Transcriptomic analysis identified 521 upregulated and 964 downregulated genes.
  • Key prognostic markers (TTK, S100A9, MACIR, AKR1B10P1, ZFPM2-AS1) associated with poor survival were identified and linked to metabolism and cancer progression pathways.

Conclusions

  • TPP exposure may enhance malignant phenotypes in prostate cancer by modulating gene expression and activating cancer-related pathways.
  • This study highlights potential health risks associated with environmental pollutants like TPP.
  • Identified genes represent candidate prognostic biomarkers for prostate cancer.

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