Subdural Hematoma in an Infant with Glutaric Aciduria Type 1: A Case Report on Conservative Management

Area of Science:

• Neurology
• Metabolic disorders
• Pediatrics

Background:

• Glutaric aciduria type 1 (GA1) is an inherited metabolic disorder.
• GA1 is associated with subdural hematomas, potentially due to widened cerebrospinal fluid spaces.
• Macrocephaly and accelerated cephalic growth can occur in infants with GA1.

Purpose of the Study:

• To present a case of an infant with GA1 and large subdural hematomas.
• To evaluate the efficacy of conservative management for subdural hematomas in GA1.
• To highlight the importance of avoiding metabolic decompensation.

Main Methods:

• Newborn screening diagnosed GA1 in an infant with congenital macrocephaly.
• Cranial MRI at eight months revealed bilateral subdural hematomas with mass effect.
• Conservative management with close monitoring was chosen over surgical intervention.

Main Results:

• The infant remained clinically stable without signs of trauma or abuse.
• Imaging demonstrated a significant reduction in subdural hematoma dimensions.
• Conservative management proved effective in resolving the hematomas.

Conclusions:

• Conservative management can be a safe and effective strategy for large subdural hematomas with mass effect in GA1.
• This approach avoids the risks associated with surgical intervention and potential metabolic decompensation.
• Close monitoring is crucial for successful conservative management in these cases.