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Updated: Sep 12, 2025
Profiling Sensitivity to Targeted Therapies in EGFR-Mutant NSCLC Patient-Derived Organoids
Published on: November 22, 2021
Investigating the correlation between IDO1/PD-L1 expression or co-expression and EGFR/KRAS gene mutations in advanced
Zhidong Yin1, Bohao Sun1, Lu Cheng1
1Department of Pathology, Second Affiliated Hospital, Zhejiang University School of Medicine, No. 88 Jiefang Road, Hangzhou, 310009, Zhejiang Province, China.
None:
Lung cancer was frequently diagnosed at advanced stages (III/IV) and exhibited poor 5-year survival due to limited treatment efficacy. While immunotherapy and targeted therapies had advanced care, drug resistance persisted as a critical challenge. Our study revealed significant IDO1/PD-L1 co-expression in NSCLC. Tumor cells from patients treated with targeted therapy, chemotherapy, or immunotherapy (mono- or combination therapy) demonstrated elevated IDO1 expression. EGFR wild-type patients predominantly showed individual or co-positive IDO1/PD-L1 expression, whereas EGFR-mutant cases typically exhibited co-negative or single-negative profiles. Notably, PD-L1 single-positive patients achieved significantly or marginally prolonged OS compared to IDO1 single-positive, co-positive, or co-negative cohorts, with this survival benefit being most pronounced in EGFR wild-type subgroups. These results indicated that combined targeting of IDO1 with PD-L1/EGFR/KRAS pathways might represent a viable therapeutic approach for advanced NSCLC.
