Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Cell Migration01:09

Cell Migration

17.2K
Cell migration, the process by which cells move from one location to another, is essential for the proper development and viability of organisms throughout their life. When cells are not able to migrate properly to their ordained locations, various disorders may occur. For example, disruption in cell migration causes chronic inflammatory diseases such as arthritis.
17.2K
Cytoskeletal Coordination in Cell Migration01:32

Cytoskeletal Coordination in Cell Migration

4.9K
A migrating cell changes its shape during the cyclic events of attachment and detachment from the substratum and repositions the cell organelles correspondingly. These complex events are orchestrated by the dynamic cytoskeletal network comprising actin filaments, intermediate filaments, and microtubules. Cytoskeletal crosstalk — the direct and indirect communication between the different components — is crucial for this coordination. Direct communication involves various linker...
4.9K
Chemotaxis and Direction of Cell Migration01:21

Chemotaxis and Direction of Cell Migration

3.5K
Cells can detect chemical cues in their environment and reorganize the cytoskeleton to migrate toward them or away from them. This directional migration, called chemotaxis, is essential during embryogenesis and development, immune response, tissue repair and regeneration, and reproduction. These chemical cues can either attract or repel the cell's movement. For example, axon development is determined by a combination of chemoattractants and chemorepellents that direct the growing axon...
3.5K
Role of Myosin in Cell Migration01:18

Role of Myosin in Cell Migration

2.4K
Myosins are multimeric motor proteins involved in various cellular processes such as migration, adhesion, and proliferation. Myosin II is the most common type in animal cells, which binds and cross-links actin filaments.
Myosin II  is a hexamer comprising two heavy chains with globular heads and coiled-coil tails, two regulatory light chains, and two essential light chains. The ATPase sites on the myosin heads hydrolyze ATP, and the released phosphate generates the force for contraction....
2.4K
Cell Polarization by Rho Proteins01:21

Cell Polarization by Rho Proteins

2.8K
Cell polarity is the asymmetric distribution of cellular and membrane components, making one side of the cell different from the other. This polarity is essential to many processes such as embryogenesis, axon migration, glucose transport across epithelial cells, and directional cell migration. A migrating cell responds to intracellular or extracellular signals via molecular cascades that reorganize the actin cytoskeleton to establish this polarity. In these cells, the Rho family proteins Cdc42,...
2.8K
Actin Polymerization and Cell Motility01:13

Actin Polymerization and Cell Motility

5.4K
Actin is a family of globular proteins that are highly abundant in eukaryotic cells. It makes up approximately 1-5% of total cell protein concentration. Actin monomers polymerize to form a complex network of polarized filaments, the actin cytoskeleton, that plays a crucial role in many cellular processes, including cell motility, division, endocytosis, and metastasis of cancer cells.
Actin cytoskeleton dynamics can produce pushing, pulling, and resistance forces that help the cell to migrate....
5.4K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Enhanced integrin-mediated adhesion and proliferation of Schwann cells using highly aligned, dual-functional fibrous scaffolds.

npj soft matter·2026
Same author

Peptide concentration gradients and aligned microfiber topography synergize to speed and direct Schwann cell migration.

Acta biomaterialia·2026
Same author

Mitochondrial transfer from glia to neurons protects against peripheral neuropathy.

Nature·2026
Same author

Thermally Driven Release of Oxycodone from Poly(ester urea) Thin Films by Printed Microheaters for Transdermal Delivery.

ACS applied materials & interfaces·2025
Same author

Additive Accelerated Meloxicam Release from Poly(Ester Urea) Fiber Implants for Acute Pain Management.

Advanced healthcare materials·2025
Same author

Polysialic Acid-Functionalized MAP Scaffolds Promote Regulatory Immune Responses After Ischemic Stroke.

bioRxiv : the preprint server for biology·2025
Same journal

Application of ephrin-B2 loaded glycol chitosan-silk fibroin hydrogel in the treatment of diabetic refractory wounds.

Scientific reports·2026
Same journal

International expert Delphi consensus on thromboprophylaxis in metabolic and bariatric surgery.

Scientific reports·2026
Same journal

Assessing the cross-region knowledge transfer capability of selected deep learning building vectorization methods in the context of available training datasets.

Scientific reports·2026
Same journal

Feasibility and preliminary effects of outdoor versus indoor cognitive-motor therapy in women with Alzheimer's disease: A randomized single-blind pilot study.

Scientific reports·2026
Same journal

Hallmarks of social action in the vocal turn-taking of wild common marmosets (Callithrix jacchus).

Scientific reports·2026
Same journal

Role and mechanism of AOPPs-induced NOX4-mediated ferroptosis in intervertebral disc degeneration.

Scientific reports·2026
See all related articles

Related Experiment Video

Updated: Sep 12, 2025

Creating Adhesive and Soluble Gradients for Imaging Cell Migration with Fluorescence Microscopy
13:10

Creating Adhesive and Soluble Gradients for Imaging Cell Migration with Fluorescence Microscopy

Published on: April 4, 2013

12.7K

Sex-based differences in cell migration on aligned topographies.

Yang Hu1, Yin Mei Chan2, Nicola G Judge2

  • 1Department of Chemical Engineering, Northeastern University, Boston, MA, 02115, USA.

Scientific Reports
|August 7, 2025
PubMed
Summary
This summary is machine-generated.

Female and male cells show distinct migration patterns on biomaterials. Understanding these sex-based differences in cell migration is crucial for designing effective medical devices.

Keywords:
Cell migrationNanofibersSchwann cellsSex-based differences

More Related Videos

Concentric Gel System to Study the Biophysical Role of Matrix Microenvironment on 3D Cell Migration
11:43

Concentric Gel System to Study the Biophysical Role of Matrix Microenvironment on 3D Cell Migration

Published on: April 3, 2015

8.6K
Characterizing Cell Migration Within Three-dimensional In Vitro Wound Environments
06:10

Characterizing Cell Migration Within Three-dimensional In Vitro Wound Environments

Published on: August 16, 2017

7.8K

Related Experiment Videos

Last Updated: Sep 12, 2025

Creating Adhesive and Soluble Gradients for Imaging Cell Migration with Fluorescence Microscopy
13:10

Creating Adhesive and Soluble Gradients for Imaging Cell Migration with Fluorescence Microscopy

Published on: April 4, 2013

12.7K
Concentric Gel System to Study the Biophysical Role of Matrix Microenvironment on 3D Cell Migration
11:43

Concentric Gel System to Study the Biophysical Role of Matrix Microenvironment on 3D Cell Migration

Published on: April 3, 2015

8.6K
Characterizing Cell Migration Within Three-dimensional In Vitro Wound Environments
06:10

Characterizing Cell Migration Within Three-dimensional In Vitro Wound Environments

Published on: August 16, 2017

7.8K

Area of Science:

  • Biomaterials Science
  • Cell Biology
  • Regenerative Medicine

Background:

  • Sexual dimorphism impacts physiological and pathological responses, yet preclinical research often lacks sex-specific data.
  • In vitro studies are vital for biomaterial device design, requiring an understanding of sex-based cell behavior.

Purpose of the Study:

  • To quantitatively compare female and male cell migration on flat substrates and aligned nanofiber scaffolds.
  • To investigate the influence of fiber topography and diameter on sex-based cell migration patterns.
  • To inform the design of medical devices by considering sex as a critical factor in cell behavior.

Main Methods:

  • Utilized anomalous and random walk models to analyze cell migration.
  • Examined cell migration on flat controls and nanofiber scaffolds of varying diameters (1.2 and 1.8 µm).
  • Performed morphological analysis to assess cell shape in response to sex and fiber size.

Main Results:

  • Significant sex-based differences in cell migration were observed on flat substrates: female cells showed increased speed, while male cells exhibited higher persistence.
  • Aligned fiber topography enhanced persistence in female cells and, at the highest diameter, in male cells.
  • Sex-specific differences in speed along the axis of alignment were noted on 1.2 and 1.8 µm fibers.
  • Cell morphology was significantly influenced by both cell sex and scaffold fiber diameter.

Conclusions:

  • Cell migration behavior is sex-dependent, with distinct responses to biomaterial topography.
  • Incorporating sex as a variable in in vitro studies is essential for optimizing biomaterial device design.
  • These findings provide critical insights for developing sex-specific preclinical models and improving clinical device efficacy.