Systemic Psoriasis: From Molecular Mechanisms to Global Management Strategies.

Area of Science:

• Immunology
• Dermatology
• Genetics

Background:

• Psoriasis is a chronic, immune-mediated inflammatory disease with systemic implications.
• Genetic factors, including specific loci like HLA-C*06:02, and environmental triggers contribute to its development.
• The IL-23/Th17 axis plays a critical role in psoriasis pathogenesis, driving inflammation and keratinocyte proliferation.

Purpose of the Study:

• To synthesize current knowledge on the genetic, immunologic, and molecular mechanisms of psoriasis.
• To highlight recent advances in targeted therapies for psoriasis.
• To discuss global disparities in psoriasis care and promote equitable management.

Main Methods:

• Review of current literature on psoriasis genetics, immunology, and molecular pathways.
• Analysis of recent therapeutic strategies, including biologics and small molecule inhibitors.
• Examination of global health disparities and inclusive care approaches.

Main Results:

• Identification of over 80 genetic susceptibility loci and key variants.
• Elucidation of the central role of the IL-23/Th17 axis in disease pathogenesis.
• Demonstration of significant treatment landscape transformation through targeted therapies.

Conclusions:

• Targeted therapies modulating specific pathogenic pathways have revolutionized psoriasis treatment.
• Personalized medicine approaches hold promise for optimizing outcomes and reducing disease burden.
• Addressing global disparities is crucial for equitable and innovative psoriasis management.